Document Detail


Pleiotropic effect of anticapsin on HeLa S3 cells.
MedLine Citation:
PMID:  3450099     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Anticapsin, the terminal epoxyaminoacid moiety of tetaine, inhibits irreversibly growth of HeLa S3 cells. The antibiotic decreases to a similar extent incorporation of 3H-labelled precursors into nucleic acids and protein in intact cells: inhibition of protein synthesis prevails on prolonged incubation. Also incorporation of [3H]dTTP and [3H]UTP is inhibited in the presence of anticapsin into permeabilized cells. These effects, however, are not due to the interference with DNA or RNA polymerases since anticapsin only slightly suppresses RNA polymerase activity and has no effect on DNA polymerase in the cell-free systems. The results indicate that the mechanism of antiproliferative action of anticapsin in HeLa S3 cells differs from that of tetaine and imply that inhibition of protein synthesis might be the primary effect of anticapsin.
Authors:
B Woynarowska; A Witkowski; E Borowski
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta biochimica Polonica     Volume:  34     ISSN:  0001-527X     ISO Abbreviation:  Acta Biochim. Pol.     Publication Date:  1987  
Date Detail:
Created Date:  1988-06-16     Completed Date:  1988-06-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  14520300R     Medline TA:  Acta Biochim Pol     Country:  POLAND    
Other Details:
Languages:  eng     Pagination:  369-76     Citation Subset:  IM    
Affiliation:
Institute of Organic and Food Chemistry and Technology, Technical University of Gdańsk.
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MeSH Terms
Descriptor/Qualifier:
Alanine / analogs & derivatives*,  pharmacology
Antineoplastic Agents / pharmacology*
Cell Division / drug effects
Hela Cells / drug effects
Humans
Nucleic Acids / biosynthesis
Protein Biosynthesis*
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 0/Nucleic Acids; 28978-07-6/anticapsin; 56-41-7/Alanine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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