| Pleiotropic Effects of Nicotinic Acid: Beyond High Density Lipoprotein Cholesterol Elevation. | |
| | |
MedLine Citation:
|
PMID: 21314635 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Aims: Treatment with statins has significantly reduced cardiovascular morbidity and mortality, an effect attributed to both the low-density lipoprotein cholesterol (LDL-C) lowering capacity and the pleiotropic actions of these drugs. However, residual risk remains even after intense LDL-C lowering. Therefore, additional treatment with lipid-lowering drugs which improve other lipid parameters and have favourable non-lipid effects may be of clinical value. The aim of the present article is to review the actions of nicotinic acid and comment on the limitations and possible benefits of this drug in clinical practice. Methods: Relevant articles were identified through a Pubmed search up to July 2010. Results: Nicotinic acid (niacin) improves the lipid profile and has been associated with reduction in morbidity and mortality from cardiovascular disease. This favourable outcome may be due to several beneficial actions of this drug, such as antithrombotic, anti-inflammatory and antioxidant. However, its use has been limited due to side effects, especially flushing. A novel formulation with a prostaglandin D(2) receptor antagonist (laropiprant) appears to substantially decrease the frequency and intensity of flushing, without affecting the other properties of niacin. Some concerns regarding treatment with nicotinic acid include impaired glucose metabolism and elevations in uric acid and homocysteine levels. Conclusion: Nicotinic acid is a safe supplementary (to statins) lipid lowering agent which may also improve cardiovascular outcomes. Whether its combination with laropiprant will be proved equally effective and more favourable in terms of adverse effects remains to be established by large clinical trials. |
| | |
Authors:
|
M Florentin; E N Liberopoulos; A Kei; D P Mikhailidis; M S Elisaf |
Related Documents
:
|
8063965 - Triacylglycerol fatty acid composition of milk from periparturient cows during acute es... 20356645 - Feed supplementation of lactobacillus plantarum pca 236 modulates gut microbiota and mi... 18922195 - The effect of short-term hyperammonaemia on milk synthesis in dairy cows. 7911415 - Glucose and amino acid transport and metabolism in flat duodenal sheets of dairy cattle... 8063965 - Triacylglycerol fatty acid composition of milk from periparturient cows during acute es... 15743425 - An overview of the antifungal properties of allicin and its breakdown products--the pos... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-2-14 |
Journal Detail:
|
Title: Current vascular pharmacology Volume: - ISSN: 1875-6212 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
|
Created Date: 2011-2-14 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101157208 Medline TA: Curr Vasc Pharmacol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Clinical Biochemistry (Vascular Disease Prevention Clinics), Royal Free Campus, University College London Medical School, University College London (UCL), London, UK. MIKHAILIDIS@aol.com. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: What Restricts the Clinical Use of Nicotinic Acid?
Next Document: Atherosclerotic Renal Artery Stenosis: An Update on Diagnosis and Management.