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Pleconaril-resistant chronic parechovirus-associated enteropathy in agammaglobulinaemia.
MedLine Citation:
PMID:  21685550     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
A 14 year old common variable immunodeficiency patient developed severe protein-losing enteropathy. A chronic enteral infection with human parechovirus type 1 and norovirus was diagnosed. Treatment strategies aimed at virus eradication and providing supportive care were ineffective. The antipicornavirus agent pleconaril did not have any effect on viral replication. Symptoms improved on immunosuppressive therapy, suggesting infection-related immune dysregulation in an immunocompromised host.
Authors:
Annick Ajm van de Ven; Jan Willem Douma; Carin Rademaker; Anton M van Loon; Annemarie Mj Wensing; Jaap-Jan Boelens; Elisabeth Am Sanders; Joris M van Montfrans
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Antiviral therapy     Volume:  16     ISSN:  2040-2058     ISO Abbreviation:  Antivir. Ther. (Lond.)     Publication Date:  2011  
Date Detail:
Created Date:  2011-06-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9815705     Medline TA:  Antivir Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  611-4     Citation Subset:  IM    
Affiliation:
Department of Pediatric Immunology and Infectious Diseases, University Medical Center Utrecht/Wilhelmina Children's Hospital, Utrecht, the Netherlands.
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