Document Detail

Plausibility of HIV-1 Infection of Oral Mucosal Epithelial Cells.
MedLine Citation:
PMID:  21441479     Owner:  NLM     Status:  MEDLINE    
The AIDS pandemic continues. Little is understood about how HIV gains access to permissive cells across mucosal surfaces, yet such knowledge is crucial to the development of successful topical anti-HIV-1 agents and mucosal vaccines. HIV-1 rapidly internalizes and integrates into the mucosal keratinocyte genome, and integrated copies of HIV-1 persist upon cell passage. The virus does not appear to replicate, and the infection may become latent. Interactions between HIV-1 and oral keratinocytes have been modeled in the context of key environmental factors, including putative copathogens and saliva. In keratinocytes, HIV-1 internalizes within minutes; in saliva, an infectious fraction escapes inactivation and is harbored and transferable to permissive target cells for up to 48 hours. When incubated with the common oral pathogen Porphyromonas gingivalis, CCR5- oral keratinocytes signal through protease-activated receptors and Toll-like receptors to induce expression of CCR5, which increases selective uptake of infectious R5-tropic HIV-1 into oral keratinocytes and transfer to permissive cells. Hence, oral keratinocytes-like squamous keratinocytes of other tissues-may be targets for low-level HIV-1 internalization and subsequent dissemination by transfer to permissive cells.
M C Herzberg; A Vacharaksa; K H Gebhard; R A Giacaman; K F Ross
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Advances in dental research     Volume:  23     ISSN:  1544-0737     ISO Abbreviation:  Adv. Dent. Res.     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-03-28     Completed Date:  2011-08-03     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  8802131     Medline TA:  Adv Dent Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  38-44     Citation Subset:  D    
Department of Diagnostic and Biological Sciences, School of Dentistry, University of Minnesota, Minneapolis, Minnesota, USA.
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MeSH Terms
Dendritic Cells / virology
HIV Infections / physiopathology*
HIV-1 / physiology*
Immunity, Mucosal
Keratinocytes / virology*
Mouth Mucosa / cytology,  virology*
Porphyromonas gingivalis / physiology
Receptors, CCR5 / physiology
Receptors, CXCR / physiology
Superinfection / physiopathology
Urogenital System / virology
Virus Internalization*
Virus Latency
Virus Replication*
Grant Support
Reg. No./Substance:
0/Receptors, CCR5; 0/Receptors, CXCR

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