Document Detail


Plausibility of HIV-1 Infection of Oral Mucosal Epithelial Cells.
MedLine Citation:
PMID:  21441479     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The AIDS pandemic continues. Little is understood about how HIV gains access to permissive cells across mucosal surfaces, yet such knowledge is crucial to the development of successful topical anti-HIV-1 agents and mucosal vaccines. HIV-1 rapidly internalizes and integrates into the mucosal keratinocyte genome, and integrated copies of HIV-1 persist upon cell passage. The virus does not appear to replicate, and the infection may become latent. Interactions between HIV-1 and oral keratinocytes have been modeled in the context of key environmental factors, including putative copathogens and saliva. In keratinocytes, HIV-1 internalizes within minutes; in saliva, an infectious fraction escapes inactivation and is harbored and transferable to permissive target cells for up to 48 hours. When incubated with the common oral pathogen Porphyromonas gingivalis, CCR5- oral keratinocytes signal through protease-activated receptors and Toll-like receptors to induce expression of CCR5, which increases selective uptake of infectious R5-tropic HIV-1 into oral keratinocytes and transfer to permissive cells. Hence, oral keratinocytes-like squamous keratinocytes of other tissues-may be targets for low-level HIV-1 internalization and subsequent dissemination by transfer to permissive cells.
Authors:
M C Herzberg; A Vacharaksa; K H Gebhard; R A Giacaman; K F Ross
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Advances in dental research     Volume:  23     ISSN:  1544-0737     ISO Abbreviation:  Adv. Dent. Res.     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-03-28     Completed Date:  2011-08-03     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  8802131     Medline TA:  Adv Dent Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  38-44     Citation Subset:  D    
Affiliation:
Department of Diagnostic and Biological Sciences, School of Dentistry, University of Minnesota, Minneapolis, Minnesota, USA. mcherzb@umn.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Dendritic Cells / virology
HIV Infections / physiopathology*
HIV-1 / physiology*
Humans
Immunity, Mucosal
Keratinocytes / virology*
Mouth Mucosa / cytology,  virology*
Porphyromonas gingivalis / physiology
Receptors, CCR5 / physiology
Receptors, CXCR / physiology
Superinfection / physiopathology
Urogenital System / virology
Virus Internalization*
Virus Latency
Virus Replication*
Grant Support
ID/Acronym/Agency:
R01DE015503/DE/NIDCR NIH HHS; R21 DE015506/DE/NIDCR NIH HHS
Chemical
Reg. No./Substance:
0/Receptors, CCR5; 0/Receptors, CXCR
Comments/Corrections

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