Document Detail

Plaunotol induces a comparative increase of acidic mucin fraction in gastric juice.
MedLine Citation:
PMID:  21661449     Owner:  NLM     Status:  In-Process    
BACKGROUND/AIMS: Gastric mucus protects the gastric mucosa. Plaunotol, a gastroprotective agent, has been shown to increase mucus production in animal models. However, it is unclear whether plaunotol benefits human gastric mucus secretion.
METHODOLOGY: Twenty-five patients with atrophic gastritis were studied. All patients underwent gastroendoscopy and gastric juice was collected before and after plaunotol treatment for 3 months. Gastric juice mucin was examined by gel filtration as well as anion-exchange chromatography. The identification of each fraction was examined by enzyme-linked immunosorbent assay (ELISA) with the use of HGM75 and HIK1083, antibodies against mucin from surface mucus cells and from gastric glandular mucus cells, respectively.
RESULTS: Plaunotol significantly increased the total gastric juice volume (7.8mL before vs. 10.7mL, after administration; p=0.03). By anion exchange chromatography, we detected three mucin fractions (Fr I-III). Fr I strongly reacted with HGM75 but did not react with HIK1083. The other fractions (Fr II, III) reacted with HIK1083 but weakly reacted with HGM75. After administration of plaunotol, a significant increase in Fr III (acidic mucin) was observed (p=0.02).
CONCLUSIONS: Long-term administration of plaunotol changes the composition of gastric juice mucin, including a significant increase in the proportion of acidic mucin fraction.
Masana Tatsugami; Masanori Ito; Kazuhiko Ishihara; Ken Haruma; Masaharu Sumii; Atsunori Sasaki; Shosuke Kitamura; Akemi Takamura; Yoshihiro Wada; Yoshiaki Matsumoto; Shinobu Imagawa; Shunsuke Takata; Shinji Tanaka; Masaharu Yoshihara; Kazuaki Chayama
Related Documents :
12489879 - Direct determination of free amino acids and sugars in green tea by anion-exchange chro...
15069659 - Spacer length effect of a chiral stationary phase based on (+)-(18-crown-6)-2,3,11,12-t...
950349 - Interaction between asymmetric solutes and solvents. diamides derived from l-valine as ...
3624359 - Analysis of fatty acids as their anthrylmethyl esters by high-performance liquid chroma...
11001229 - On-column derivatization and analysis of amino acids, peptides, and alkylamines by anhy...
21737639 - Mucous gland metaplasia in the esophagus and gastric mucosa in baboons.
6337659 - Inhibition of gastric acid secretion by intracerebroventricularly administered prostagl...
15035379 - Viability of acid-adapted escherichia coli o157:h7 in ground beef treated with acidic c...
3477209 - A polarized light and scanning electron microscopic study of sodium-fluoride treated, a...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hepato-gastroenterology     Volume:  58     ISSN:  0172-6390     ISO Abbreviation:  Hepatogastroenterology     Publication Date:    2011 Mar-Apr
Date Detail:
Created Date:  2011-06-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8007849     Medline TA:  Hepatogastroenterology     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  663-8     Citation Subset:  IM    
Department of Medicine and Molecular Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Low peritoneal and systemic inflammatory response after laparoscopy-assisted gastrectomy compared to...
Next Document:  Study for the quality of life following total gastrectomy of gastric carcinoma.