| Plaunotol induces a comparative increase of acidic mucin fraction in gastric juice. | |
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MedLine Citation:
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PMID: 21661449 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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BACKGROUND/AIMS: Gastric mucus protects the gastric mucosa. Plaunotol, a gastroprotective agent, has been shown to increase mucus production in animal models. However, it is unclear whether plaunotol benefits human gastric mucus secretion. METHODOLOGY: Twenty-five patients with atrophic gastritis were studied. All patients underwent gastroendoscopy and gastric juice was collected before and after plaunotol treatment for 3 months. Gastric juice mucin was examined by gel filtration as well as anion-exchange chromatography. The identification of each fraction was examined by enzyme-linked immunosorbent assay (ELISA) with the use of HGM75 and HIK1083, antibodies against mucin from surface mucus cells and from gastric glandular mucus cells, respectively. RESULTS: Plaunotol significantly increased the total gastric juice volume (7.8mL before vs. 10.7mL, after administration; p=0.03). By anion exchange chromatography, we detected three mucin fractions (Fr I-III). Fr I strongly reacted with HGM75 but did not react with HIK1083. The other fractions (Fr II, III) reacted with HIK1083 but weakly reacted with HGM75. After administration of plaunotol, a significant increase in Fr III (acidic mucin) was observed (p=0.02). CONCLUSIONS: Long-term administration of plaunotol changes the composition of gastric juice mucin, including a significant increase in the proportion of acidic mucin fraction. |
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Authors:
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Masana Tatsugami; Masanori Ito; Kazuhiko Ishihara; Ken Haruma; Masaharu Sumii; Atsunori Sasaki; Shosuke Kitamura; Akemi Takamura; Yoshihiro Wada; Yoshiaki Matsumoto; Shinobu Imagawa; Shunsuke Takata; Shinji Tanaka; Masaharu Yoshihara; Kazuaki Chayama |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Hepato-gastroenterology Volume: 58 ISSN: 0172-6390 ISO Abbreviation: Hepatogastroenterology Publication Date: 2011 Mar-Apr |
Date Detail:
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Created Date: 2011-06-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8007849 Medline TA: Hepatogastroenterology Country: Greece |
Other Details:
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Languages: eng Pagination: 663-8 Citation Subset: IM |
Affiliation:
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Department of Medicine and Molecular Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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