Document Detail


Plaunotol induces apoptosis of gastric cancer cells.
MedLine Citation:
PMID:  17691055     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Although some isoprenoids, such as taxans and geranylgeraniol (GGOH), have been reported to have strong anticancer activities, the effect of plaunotol, the isoprenoid extracted from the leaves of Plau-noi, on cancer has not yet been evaluated. Here, we aimed to investigate the effect of plaunotol on gastric cancer cell lines. Three gastric cancer cell lines, namely MKN-45, MKN-74 and AZ-521 were used. Plaunotol was tested at 10, 20, 30 and 40 micromol/L. Plaunotol dose-dependently inhibited the growth of all gastric cancer cells, dependent on the induction of apoptosis. Caspases-8, -9 and -3, were found to be activated in the apoptotic cells. The expression of Bax protein was increased, but Bcl-2 and Bcl-xL protein expressions were not significantly affected. Plaunotol should be a promising new antitumor agent, and since it is already available for clinical use in Japan, its anticancer properties should be confirmed in clinical trials.
Authors:
Jun Yamada; Kazushige Kawai; Nelson H Tsuno; Joji Kitayama; Takeshi Tsuchiya; Satomi Yoneyama; Masahiro Asakage; Yurai Okaji; Koki Takahashi; Hirokazu Nagawa
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-08-09
Journal Detail:
Title:  Planta medica     Volume:  73     ISSN:  0032-0943     ISO Abbreviation:  Planta Med.     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-08-24     Completed Date:  2007-11-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0066751     Medline TA:  Planta Med     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1068-73     Citation Subset:  IM    
Affiliation:
Department of Surgical Oncology, Faculty of Medicine, University of Tokyo, Tokyo, Japan. jymda-tky@umin.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Antineoplastic Agents, Phytogenic / administration & dosage,  pharmacology*,  therapeutic use
Apoptosis / drug effects*
Caspases / metabolism
Cell Line, Tumor / drug effects
Croton*
Dose-Response Relationship, Drug
Fatty Alcohols / administration & dosage,  pharmacology*,  therapeutic use
Flow Cytometry
Humans
In Situ Nick-End Labeling
Phytotherapy*
Plant Extracts / administration & dosage,  pharmacology,  therapeutic use
Stomach Neoplasms / pathology
Chemical
Reg. No./Substance:
0/Antineoplastic Agents, Phytogenic; 0/Fatty Alcohols; 0/Plant Extracts; 64218-02-6/plaunotol; EC 3.4.22.-/Caspases

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