Document Detail


Platinum chemotherapy during pregnancy for serous cystadenocarcinoma of the ovary.
MedLine Citation:
PMID:  8482567     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ovarian carcinoma in pregnancy remains a rare event. Although concern regarding the gestation complicates therapy, platinum drug-based combination chemotherapy is often deemed warranted in such cases. We report the antepartum use of cisplatin, followed by carboplatin, for an ovarian serous cystadenocarcinoma. During this treatment, serial sonographic assessment of fetal morphometric parameters and biophysical profiles with fetal heart rate monitoring were performed to document fetal well being. Platinum-DNA adducts were measured in maternal blood, placenta, fetal amniotic cells, and cord blood. This report represents an attempt to define platinum drug transfer in utero and fetal growth and development during therapy and to document the first use of carboplatin in pregnancy.
Authors:
C E Henderson; G Elia; D Garfinkel; M C Poirier; H Shamkhani; C D Runowicz
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Gynecologic oncology     Volume:  49     ISSN:  0090-8258     ISO Abbreviation:  Gynecol. Oncol.     Publication Date:  1993 Apr 
Date Detail:
Created Date:  1993-06-02     Completed Date:  1993-06-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0365304     Medline TA:  Gynecol Oncol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  92-4     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, Jack D. Weiler Hospital, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, New York.
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MeSH Terms
Descriptor/Qualifier:
Adult
Carboplatin / therapeutic use*
Cisplatin / therapeutic use*
Cystadenocarcinoma / drug therapy*
Female
Humans
Infant, Newborn
Male
Ovarian Neoplasms / drug therapy*
Pregnancy
Pregnancy Complications, Neoplastic / drug therapy*
Pregnancy Outcome
Treatment Outcome
Chemical
Reg. No./Substance:
15663-27-1/Cisplatin; 41575-94-4/Carboplatin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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