Document Detail

The Platelia Aspergillus ELISA in diagnosis of invasive pulmonary aspergilosis (IPA).
MedLine Citation:
PMID:  11714060     Owner:  NLM     Status:  MEDLINE    
The sensitivity of a sandwich enzyme-linked immunosorbent assay (ELISA) for detecting Aspergillus galactomannan was evaluated with 66 serum samples and 113 specimens of the respiratory tract obtained from 52 patients with pulmonary diseases. The patients were divided into five groups: proven invasive pulmonary aspergillosis (IPA) (five patients), probable IPA (seven patients), Aspergillus colonization (eight patients) or unlikely Aspergillus infection (27 patients). Another five patients with doubtful diagnostic test results are discussed in detail. The results of the Platelia Aspergillus ELISA (Sanofi Pasteur, Freiburg, Germany) in testing specimens of the respiratory tract were 90% sensitivity in proven (serum 38%), 60% in probable (serum 37%) and 71% in Aspergillus colonization (serum 0%). Furthermore, 85% of the Aspergillus spp. from positive cultures of specimens of the respiratory tract were also detected in the ELISA. A total of 57% of the culture negative specimens of patients with a least one positive culture or proven aspergillosis in a series of specimens were positive in the ELISA.
M Siemann; M Koch-Dörfler
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Mycoses     Volume:  44     ISSN:  0933-7407     ISO Abbreviation:  Mycoses     Publication Date:  2001  
Date Detail:
Created Date:  2001-11-20     Completed Date:  2002-03-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8805008     Medline TA:  Mycoses     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  266-72     Citation Subset:  IM    
Pathologisch-Bakteriologisches Institut, Städtisches Krankrenhaus, Kiel, Germany.
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MeSH Terms
Antigens, Fungal / blood
Aspergillosis / diagnosis*,  immunology
Aspergillus / immunology*
Enzyme-Linked Immunosorbent Assay / methods*
False Positive Reactions
Lung Diseases, Fungal / diagnosis*,  immunology
Mannans / immunology
Middle Aged
Sensitivity and Specificity
Reg. No./Substance:
0/Antigens, Fungal; 0/Mannans; 11078-30-1/galactomannan

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