| The Platelia Aspergillus ELISA in diagnosis of invasive pulmonary aspergilosis (IPA). | |
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MedLine Citation:
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PMID: 11714060 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The sensitivity of a sandwich enzyme-linked immunosorbent assay (ELISA) for detecting Aspergillus galactomannan was evaluated with 66 serum samples and 113 specimens of the respiratory tract obtained from 52 patients with pulmonary diseases. The patients were divided into five groups: proven invasive pulmonary aspergillosis (IPA) (five patients), probable IPA (seven patients), Aspergillus colonization (eight patients) or unlikely Aspergillus infection (27 patients). Another five patients with doubtful diagnostic test results are discussed in detail. The results of the Platelia Aspergillus ELISA (Sanofi Pasteur, Freiburg, Germany) in testing specimens of the respiratory tract were 90% sensitivity in proven (serum 38%), 60% in probable (serum 37%) and 71% in Aspergillus colonization (serum 0%). Furthermore, 85% of the Aspergillus spp. from positive cultures of specimens of the respiratory tract were also detected in the ELISA. A total of 57% of the culture negative specimens of patients with a least one positive culture or proven aspergillosis in a series of specimens were positive in the ELISA. |
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Authors:
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M Siemann; M Koch-Dörfler |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Mycoses Volume: 44 ISSN: 0933-7407 ISO Abbreviation: Mycoses Publication Date: 2001 |
Date Detail:
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Created Date: 2001-11-20 Completed Date: 2002-03-27 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8805008 Medline TA: Mycoses Country: Germany |
Other Details:
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Languages: eng Pagination: 266-72 Citation Subset: IM |
Affiliation:
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Pathologisch-Bakteriologisches Institut, Städtisches Krankrenhaus, Kiel, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Antigens, Fungal / blood Aspergillosis / diagnosis*, immunology Aspergillus / immunology* Enzyme-Linked Immunosorbent Assay / methods* False Positive Reactions Female Humans Lung Diseases, Fungal / diagnosis*, immunology Male Mannans / immunology Middle Aged Sensitivity and Specificity |
| Chemical | |
Reg. No./Substance:
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0/Antigens, Fungal; 0/Mannans; 11078-30-1/galactomannan |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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