Document Detail


Platelets release CXCL4L1, a nonallelic variant of the chemokine platelet factor-4/CXCL4 and potent inhibitor of angiogenesis.
MedLine Citation:
PMID:  15459074     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Platelet factor-4 (PF-4)/CXCL4 was the first chemokine described to inhibit neovascularization. Here, the product of the nonallelic variant gene of CXCL4, PF-4var1/PF-4alt, designated CXCL4L1, was isolated for the first time from thrombin-stimulated human platelets and purified to homogeneity. Although secreted CXCL4 and CXCL4L1 differ in only three amino acids, CXCL4L1 was more potent in inhibiting chemotaxis of human microvascular endothelial cells toward interleukin-8 (IL-8)/CXCL8 or basic fibroblast growth factor (bFGF). In vivo, CXCL4L1 was also more effective than CXCL4 in inhibiting bFGF-induced angiogenesis in rat corneas. Thus, activated platelets release CXCL4L1, a potent regulator of endothelial cell biology, which affects angiogenesis and vascular diseases.
Authors:
Sofie Struyf; Marie D Burdick; Paul Proost; Jo Van Damme; Robert M Strieter
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.     Date:  2004-09-30
Journal Detail:
Title:  Circulation research     Volume:  95     ISSN:  1524-4571     ISO Abbreviation:  Circ. Res.     Publication Date:  2004 Oct 
Date Detail:
Created Date:  2004-10-29     Completed Date:  2005-05-12     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0047103     Medline TA:  Circ Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  855-7     Citation Subset:  IM    
Affiliation:
Laboratory of Molecular Immunology, Rega Institute, University of Leuven, Minderbroedersstraat 10, B-3000 Leuven, Belgium.
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MeSH Terms
Descriptor/Qualifier:
Alleles
Amino Acid Sequence
Angiostatic Proteins / genetics,  isolation & purification,  pharmacology,  secretion*
Animals
Blood Platelets / drug effects,  secretion*
Cells, Cultured / drug effects,  physiology
Chemotaxis / drug effects
Corneal Neovascularization / chemically induced
Culture Media, Conditioned / pharmacology
Cytoplasmic Granules / drug effects,  secretion
Endothelial Cells / drug effects,  physiology
Endothelium, Vascular / cytology
Enzyme-Linked Immunosorbent Assay
Fibroblast Growth Factor 2 / antagonists & inhibitors,  pharmacology
Humans
Interleukin-8 / antagonists & inhibitors,  pharmacology
Molecular Sequence Data
Platelet Activation
Platelet Factor 4 / genetics,  isolation & purification,  pharmacology,  secretion*
Rats
Structure-Activity Relationship
Thrombin / pharmacology
Grant Support
ID/Acronym/Agency:
CA87879/CA/NCI NIH HHS; HL66027/HL/NHLBI NIH HHS; P50CA90388/CA/NCI NIH HHS; P50HL67665/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Angiostatic Proteins; 0/Culture Media, Conditioned; 0/Interleukin-8; 0/PF4V1 protein, human; 103107-01-3/Fibroblast Growth Factor 2; 37270-94-3/Platelet Factor 4; EC 3.4.21.5/Thrombin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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