Document Detail

Platelets prevent acute liver damage after extended hepatectomy in pigs.
MedLine Citation:
PMID:  20734209     Owner:  NLM     Status:  MEDLINE    
BACKGROUND/PURPOSE: Platelets develop tissue repair and promote liver regeneration. We investigated whether platelets prevented acute liver damage after extended hepatectomy in pigs.
METHODS: Thrombocytosis was induced by the following two methods; afterwards 80% hepatectomy was performed in pigs. In the first method, the pigs received administration of thrombopoietin [TPO (+) group], and they were compared with a control group [TPO (-) group]. In the second method, the pigs received a splenectomy [Sp (+) group], and theywere compared with another control group [Sp (-) group]. Platelet counts, biochemical examination of blood, and histopathological findings of the residual liver were examined.
RESULTS: Serum aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), and total bilirubin (T-Bil) levels were significantly decreased in the thrombocytotic groups compared with the control groups in the early period after hepatectomy. In the histopathological findings, hemorrhagic necrosis with a bile plug was observed in the control groups, but this phenomenon was not observed in the thrombocytotic groups. On transmission electron microscopy, the sinusoidal endothelial lining was destroyed and detached into the sinusoidal space with enlargement of Disse's spaces in the thrombocytotic groups, but these findings were not observed in the control groups.
CONCLUSION: An increased number of platelets prevents acute liver damage after extended hepatectomy.
Katsuji Hisakura; Soichiro Murata; Kiyoshi Fukunaga; Andriy Myronovych; Sosuke Tadano; Takuya Kawasaki; Keisuke Kohno; Osamu Ikeda; Sugiru Pak; Naoya Ikeda; Yoritaka Nakano; Ryota Matsuo; Kenjiro Konno; Eiji Kobayashi; Toshiyuki Saito; Hiroshi Yasue; Nobuhiro Ohkohchi
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2010-04-14
Journal Detail:
Title:  Journal of hepato-biliary-pancreatic sciences     Volume:  17     ISSN:  1868-6982     ISO Abbreviation:  J Hepatobiliary Pancreat Sci     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-08-24     Completed Date:  2011-01-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101528587     Medline TA:  J Hepatobiliary Pancreat Sci     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  855-64     Citation Subset:  IM    
Department of Surgery, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, 305-8575, Japan.
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MeSH Terms
Acute Lung Injury / blood,  etiology,  prevention & control*
Alanine Transaminase / blood
Alkaline Phosphatase / blood
Aspartate Aminotransferases / blood
Bilirubin / blood
Blood Platelets / physiology*
Disease Models, Animal
Dose-Response Relationship, Drug
Hepatectomy / adverse effects*
Platelet Count
Splenectomy / methods
Swine, Miniature
Thrombocytosis / blood*
Thrombopoietin / administration & dosage,  therapeutic use*
Treatment Outcome
Reg. No./Substance:
635-65-4/Bilirubin; 9014-42-0/Thrombopoietin; EC Aminotransferases; EC Transaminase; EC Phosphatase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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