Document Detail


Platelets, inflammation, and prediction of the hypertension disorders of pregnancy.
MedLine Citation:
PMID:  21405944     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Objective. To assess the features of the platelets (PLTs) of hypertensive disorders of pregnancy (HDP) and to determine whether they have a predictive value for the disorders during the preclinical stage. Methods. This study included 461 HDPs and 827 normal pregnancies. Platelet counts were compared between the two groups by an independent samples t test; a Fisher's linear discriminant analysis and receiver operator characteristic curve were performed to analyze the diagnostic effects of the variables in developing HDP. Results. Women with HDP had significantly higher PLT before the second trimester. When exceeding the cut-off, it had a specificity (SPE) of 81.67% (95% CI: 81.63%-81.72%) for predicting a HDP. The discriminant function had a sensitivity of 69.1 (95% CI: 69.04-69.16), a SPE of 73.60% (95% CI: 73.569-73.64), a positive prediction value of 61.32% (95% CI: 61.25-61.39), a negative prediction value of 79.93% (95% CI: 79.88-79.98), and 71.50% of gravidas were correctly classified. Conclusion. These results show that HDP is associated with increased systemic inflammation as depicted by the PLT and white blood cells in gravidas. The discriminant function of blood cells in a mathematical model may be helpful for predicting a HDP in presymptomatic patients, however, which is not sufficiently to use in clinical practice; a prospective study about the predicting is still needed.
Authors:
Hongling Yang; Wen Tang; Chunyan Zhu; Caijiao Guo
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-15
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  -     ISSN:  1476-4954     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-3-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Clinical Laboratory, Guangzhou Women and Children's Medical Center, Guangzhou Medical College, Guangzhou, Guangdong, 510623, China.
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