| Platelet transfusion in an infant leading to formation of anti-D: implications for immunoprophylaxis. | |
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MedLine Citation:
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PMID: 15104657 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The immature infant immune system rarely makes RBC alloantibodies; however, most studies confirming the absence of alloantibodies in infants have involved transfusions that were matched for one of the most immunogenic antigens, rhesus D. The potential for D- infants to develop anti-D is unknown. Specifically, this issue has not been analyzed for infants receiving whole-blood-derived PLTs from D+ donors. The importance of understanding such risk is underscored by the fact that anti-D formation can be prevented by the administration of Rh immunoglobulin. CASE REPORT: A D- infant with congenital heart disease received two D-mismatched whole-blood-derived PLT units at 17 weeks of age. He did not receive Rh immunoglobulin prophylaxis. Upon a subsequent admission 13 months later, anti-D was identified in his plasma sample. CONCLUSION: The case presented here demonstrates that a young infant can respond to less than 0.6 mL of D+ RBCs and documents the youngest patient to have developed a RBC alloantibody from a PLT transfusion. To prevent anti-D formation, we recommend administering Rh immunoglobulin to all D- pediatric patients that receive PLT transfusions from D+ donors [correction]. |
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Authors:
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Richard L Haspel; Lorna Walsh; Steven R Sloan |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Transfusion Volume: 44 ISSN: 0041-1132 ISO Abbreviation: Transfusion Publication Date: 2004 May |
Date Detail:
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Created Date: 2004-04-23 Completed Date: 2004-06-02 Revised Date: 2005-04-12 |
Medline Journal Info:
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Nlm Unique ID: 0417360 Medline TA: Transfusion Country: United States |
Other Details:
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Languages: eng Pagination: 747-9 Citation Subset: IM |
Affiliation:
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Pathology Department, Brigham and Women's Hospital, Boston, Massachusetts, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Humans Infant, Newborn Isoantibodies / biosynthesis* Male Platelet Transfusion* Rho(D) Immune Globulin / immunology* |
| Chemical | |
Reg. No./Substance:
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0/Isoantibodies; 0/RHO(D) antibody; 0/Rho(D) Immune Globulin |
| Comments/Corrections | |
Comment In:
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Transfusion. 2005 Mar;45(3):453; author reply 453-4
[PMID:
15752167
]
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Erratum In:
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Transfusion. 2004 Aug;44(8):1270 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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