Document Detail


Platelet storage and transfusions: new concerns associated with an old therapy.
MedLine Citation:
PMID:  22662018     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Platelet transfusion has long been practiced with rudimentary knowledge about optimal storage conditions and their implications for efficacy and, particularly, safety. Recent concerns about complications such as inflammation, thrombosis and altered recipient immunity have been raised about platelet transfusion. This review will discuss recent important findings that have raised these issues about platelet transfusion associated morbidity, mortality and the possible role of platelet storage in these associations.
Authors:
Julie Sahler; Katie Grimshaw; Sherry L Spinelli; Majed A Refaai; Richard P Phipps; Neil Blumberg
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-7-20
Journal Detail:
Title:  Drug discovery today. Disease mechanisms     Volume:  8     ISSN:  1740-6765     ISO Abbreviation:  -     Publication Date:  2011  
Date Detail:
Created Date:  2012-6-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101235075     Medline TA:  Drug Discov Today Dis Mech     Country:  -    
Other Details:
Languages:  ENG     Pagination:  e9-e14     Citation Subset:  -    
Affiliation:
Department of Microbiology and Immunology, University of Rochester.
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