| Platelet reactivity in human aortic grafts: a prospective, randomized midterm study of platelet adherence and release products in Dacron and polytetrafluoroethylene conduits. | |
| | |
MedLine Citation:
|
PMID: 2537433 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Platelet-related phenomena at the blood-surface interface of randomly placed knitted Dacron (n = 6) and polytetrafluoroethylene (ePTFE) (n = 6) interposition aortic grafts were studied in patients undergoing abdominal aortic aneurysmectomy. Luminal accumulation of platelets was assessed by infusing indium-111-oxine (400 microCi) labeled autologous platelets and imaging grafts at 1 week, 3 months, and 6 months after surgery. Image analysis included an indium ratio technique (comparing aortic graft radioactivity to that of an iliac artery) and a red blood cell technetium subtraction technique (excluding blood pool radioactivity from graft radioactivity, with the heart or iliac artery serving as reference regions). Plasma levels of beta-thromboglobulin and platelet factor 4 were correlated with platelet accumulations on the aortic prostheses. Differences in graft radioactivity or platelet-release products were not evident 1 week after surgery. Three months after implantation, Dacron and ePTFE conduits exhibited 87% and 47% (p less than 0.05) more radioactivity with the indium ratio technique than the iliac artery. Similarly, increased Dacron compared with ePTFE graft radioactivity was noted using technetium subtraction techniques: 71% vs 30% with a heart reference and 26% vs 11% with an iliac artery reference, respectively. Increases in graft radioactivity correlated with increases in both plasma beta-thromboglobulin and platelet factor 4 at 3 months (r = 0.6 to 0.9; p less than 0.05 to 0.001 depending on the imaging technique used). At 6 months, differences did not persist. In fact, technetium subtraction techniques suggested less Dacron conduit reactivity. It is speculated that differences in platelet accumulation and activation associated with different graft substrates may prove clinically important. |
| | |
Authors:
|
T W Wakefield; B L Shulkin; E P Fellows; N A Petry; S A Spaulding; J C Stanley |
Related Documents
:
|
22566603 - Platelets support a protective immune response to lcmv by preventing splenic necrosis. 10737563 - Effects of the thromboxane a2 receptor antagonist on platelet deposition and intimal hy... 16785823 - The pgh-synthase system and isozyme-selective inhibition. |
Publication Detail:
|
Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Journal of vascular surgery Volume: 9 ISSN: 0741-5214 ISO Abbreviation: J. Vasc. Surg. Publication Date: 1989 Feb |
Date Detail:
|
Created Date: 1989-03-27 Completed Date: 1989-03-27 Revised Date: 2012-10-03 |
Medline Journal Info:
|
Nlm Unique ID: 8407742 Medline TA: J Vasc Surg Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 234-43 Citation Subset: IM |
Affiliation:
|
Department of Surgery, University of Michigan Medical Center, Ann Arbor 48109-0329. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Aorta, Abdominal / surgery* Aortic Aneurysm / surgery* Blood Platelets / physiology* Blood Vessel Prosthesis* Erythrocytes Humans Indium Radioisotopes / diagnostic use Middle Aged Platelet Aggregation* Polyethylene Terephthalates* Polytetrafluoroethylene* Prospective Studies Radionuclide Imaging Random Allocation Sodium Pertechnetate Tc 99m / diagnostic use |
| Grant Support | |
ID/Acronym/Agency:
|
5 MO1RR42/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Indium Radioisotopes; 0/Polyethylene Terephthalates; 23288-60-0/Sodium Pertechnetate Tc 99m; 9002-84-0/Polytetrafluoroethylene |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Critical carotid stenoses: morphologic and chemical similarity between symptomatic and asymptomatic ...
Next Document: Cellular, enzymatic, and genetic factors in the pathogenesis of abdominal aortic aneurysms.