Document Detail


Platelet monoamine oxidase activity and deficit syndrome schizophrenia.
MedLine Citation:
PMID:  7792339     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Measures of affective flattening that combine self-reported emotional experience with observed affect may identify deficit syndrome patients better than ratings based on observed affect alone. In this study, we examined 23 clinically stable but chronically ill schizophrenic patients, 15 of whom were found to have a deficit syndrome. After exclusion of patients with self-reported depressed mood from the deficit syndrome group, the remaining patients with a deficit syndrome not accompanied by self-reported depressed mood showed a strikingly homogeneous distribution of platelet monoamine oxidase activity. Results suggest that inclusion of self-reported emotional experience in clinical definitions of the deficit syndrome will increase the specificity of diagnosis.
Authors:
J A Samson; R J Gurrera; L Nisenson; J J Schildkraut
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Psychiatry research     Volume:  56     ISSN:  0165-1781     ISO Abbreviation:  Psychiatry Res     Publication Date:  1995 Jan 
Date Detail:
Created Date:  1995-07-27     Completed Date:  1995-07-27     Revised Date:  2008-04-17    
Medline Journal Info:
Nlm Unique ID:  7911385     Medline TA:  Psychiatry Res     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  25-31     Citation Subset:  IM    
Affiliation:
Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA 02178, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Affective Symptoms / diagnosis,  enzymology*,  psychology
Aged
Blood Platelets / metabolism*
Chronic Disease
Depression / diagnosis,  enzymology,  psychology
Emotions / physiology
Humans
Male
Middle Aged
Monoamine Oxidase / blood*
Personality Assessment
Psychiatric Status Rating Scales
Reference Values
Schizophrenia / diagnosis,  enzymology*
Schizophrenic Psychology*
Grant Support
ID/Acronym/Agency:
MH-15413/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
EC 1.4.3.4/Monoamine Oxidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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