| Platelet levels of reduced glutathione, superoxide dismutase, zinc and malondialdehyde in uremic patients. | |
| | |
MedLine Citation:
|
PMID: 1291855 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Platelet-reduced glutathione (GSH), superoxide dismutase (SOD) and zinc content as well as malondialdehyde (MDA) formation were studied in 24 healthy volunteers as controls and 25 patients with chronic renal failure. Uremic patients had a significantly lower GSH and SOD content as well as an abnormal MDA formation in platelets. Their plasma zinc levels were sharply below the normal value, but the platelet zinc content was similar to normal controls. The decrease in the platelet GSH level was closely related to plasma zinc in uremic patients. We also found that the platelet zinc levels were positively correlated to the platelet GSH content in normal controls and uremic patients, but not to the platelet SOD level. The results suggest that uremic toxins may influence the content of platelet GSH and SOD, as well as inhibit prostaglandin synthesis. The decreases in platelet GSH may partially be related to the low plasma zinc level. |
| | |
Authors:
|
S M Chen; T K Young |
Related Documents
:
|
8866825 - Involvement of nitric oxide in nitroprusside-induced hepatocyte cytotoxicity. 11170735 - Further evidence for mitochondrial dysfunction in progressive supranuclear palsy. 15310855 - Mitochondrial permeability transition as the critical target of n-acetyl perfluorooctan... 22826445 - Murine monoclonal antibody to platelet factor 4/heparin complexes as a potential refere... 5212405 - Ultrastructure of thrombosthenin, the contractile protein of human blood platelets. 16131385 - Evaluation of bact/alert plastic culture bottles for use in testing pooled whole blood-... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Mineral and electrolyte metabolism Volume: 18 ISSN: 0378-0392 ISO Abbreviation: Miner Electrolyte Metab Publication Date: 1992 |
Date Detail:
|
Created Date: 1993-04-01 Completed Date: 1993-04-01 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 7802196 Medline TA: Miner Electrolyte Metab Country: SWITZERLAND |
Other Details:
|
Languages: eng Pagination: 349-53 Citation Subset: IM |
Affiliation:
|
Department of Medical Research, Veterans General Hospital-Taipei, Taiwan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Blood Platelets / chemistry* Free Radicals Glutathione / blood* Humans Malondialdehyde / blood* Middle Aged Superoxide Dismutase / blood* Uremia / blood* Zinc / blood* |
| Chemical | |
Reg. No./Substance:
|
0/Free Radicals; 542-78-9/Malondialdehyde; 70-18-8/Glutathione; 7440-66-6/Zinc; EC 1.15.1.1/Superoxide Dismutase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Stimulation of renal prostanoid synthesis by potassium loading in the rat.
Next Document: Acute renal denervation decreases tubular phosphate reabsorption.