| Platelet glycoprotein Ib alpha receptor polymorphisms and recurrent ischaemic events in acute coronary syndrome patients. | |
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MedLine Citation:
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PMID: 11994555 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: To examine the relationship between polymorphisms in the platelet receptor glycoprotein (GP) Ib(alpha) and recurrent ischaemic events, and assess their impact on response to anti-platelet treatment. METHODS AND RESULTS: 1014 patients presenting with unstable coronary syndrome were recruited from the OPUS-TIMI 16 clinical trial of the platelet GPIIb/IIIa antagonist, orbofiban. The subjects were genotyped for two polymorphisms in the gene for GPIb(alpha). These were a T-5C polymorphism in the 5' untranslated Kozak region of the GPIb(alpha) gene, and the variable number of tandem repeats (VNTR) in the macroglycopeptide region.165 patients had events (recurrent ischaemia, urgent revascularisation, myocardial infarction (MI), stroke and death). There was no effect of the number of -5C alleles on composite endpoint frequency among Caucasian subjects (test for trend, p = 0.47). However, MI risk increased with the number of -5C alleles carried, with MI occurring in 2.3% of patients with the -5T/-5T genotype, 5.0% of -5T/-5C, and 16.7% of -5C/-5C (p < 0.01). The effect of treatment on MI outcome was not significantly modified by genotype (test for interaction, p = 0.10). The overall risk of bleeding was not strongly influenced by either the -5C or the VNTR polymorphisms. CONCLUSION: In an unstable coronary syndrome population the T-5C polymorphism in GPIb(alpha) influences risk of subsequent MI. |
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Authors:
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Dermot Kenny; Clare Muckian; Desmond J Fitzgerald; Christopher P Cannon; Denis C Shields |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of thrombosis and thrombolysis Volume: 13 ISSN: 0929-5305 ISO Abbreviation: J. Thromb. Thrombolysis Publication Date: 2002 Feb |
Date Detail:
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Created Date: 2002-05-07 Completed Date: 2002-12-23 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9502018 Medline TA: J Thromb Thrombolysis Country: Netherlands |
Other Details:
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Languages: eng Pagination: 13-9 Citation Subset: IM |
Affiliation:
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Department of Clinical Pharmacology, Royal College of Surgeons in Ireland, 123 St. Stephen's Green, Dublin 2, Ireland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Aged Alleles Analysis of Variance Confidence Intervals Coronary Disease / drug therapy, genetics Female Humans Male Middle Aged Minisatellite Repeats / genetics Myocardial Ischemia / drug therapy, genetics* Odds Ratio Platelet Glycoprotein GPIb-IX Complex / antagonists & inhibitors, genetics* Polymorphism, Genetic / genetics* Receptors, Cell Surface / genetics* Risk Factors |
| Chemical | |
Reg. No./Substance:
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0/Platelet Glycoprotein GPIb-IX Complex; 0/Receptors, Cell Surface |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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