| Platelet function disorders in north India. | |
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MedLine Citation:
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PMID: 8156036 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Platelet function disorders are a fairly common cause of bleeding manifestations. Although their relative types and incidence are well documented, data from India are lacking. METHODS: Between 1970 and 1991, we studied the clinical and laboratory features of 144 north Indian patients who presented to our hospital with a bleeding diathesis in whom coagulation disorders, von Willebrand's disease and a history of drug ingestion were absent. RESULTS: Isolated platelet factor 3 availability defect was the commonest (56 cases) followed by the thrombasthenias (49 cases), arachidonic acid pathway defect (26 cases), storage pool disease (8 cases) and the Bernard-Soulier syndrome (3 cases). Isolated platelet factor 3 deficiency was rare (2 cases). Two varieties of thrombasthenia were seen--the classical Glanzmann's (13 cases) and thrombopathic (36 cases). The latter was characterized by absent or sub-normal platelet aggregation with agonists along with a reduced (to less than 50% of normal) total platelet factor 3 content. This has not been reported from western countries. Patients with classical Glanzmann's thrombopathic thrombasthenia with absent platelet aggregation and isolated platelet factor 3 deficiency were severe bleeders. Their family history suggested an autosomal recessive transmission in Glanzmann's and thrombopathic thrombasthenia and a possible autosomal dominant transmission in isolated platelet factor 3 availability defect and isolated platelet factor 3 deficiency. CONCLUSION: The frequency of various types of platelet function disorders in Indians is similar to that in western populations except that the incidence of thrombopathic thrombasthenias is higher in India. |
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Authors:
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A K Saraya; R Saxena; P S Dhot; V P Choudhry; H Pati |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The National medical journal of India Volume: 7 ISSN: 0970-258X ISO Abbreviation: Natl Med J India Publication Date: 1994 Jan-Feb |
Date Detail:
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Created Date: 1994-05-19 Completed Date: 1994-05-19 Revised Date: 2010-03-24 |
Medline Journal Info:
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Nlm Unique ID: 8809315 Medline TA: Natl Med J India Country: INDIA |
Other Details:
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Languages: eng Pagination: 5-7 Citation Subset: IM |
Affiliation:
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All India Institute of Medical Sciences, Ansari Nagar, New Delhi. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Blood Platelet Disorders / epidemiology* Child Child, Preschool Female Humans India / epidemiology Infant Male Middle Aged Retrospective Studies |
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