Document Detail


Platelet-derived growth factor is structurally related to the putative transforming protein p28sis of simian sarcoma virus.
MedLine Citation:
PMID:  6306471     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A partial amino acid sequence of human platelet-derived growth factor, the major mitogen in serum for cells of mesenchymal origin, has been determined. A region of 104 contiguous amino acids shows virtual identity with the predicted sequence of p28sis, the putative transforming protein of simian sarcoma virus (SSV). This similarity suggests a mechanism for transformation by SSV and other agents, involving expression of growth factors.
Authors:
M D Waterfield; G T Scrace; N Whittle; P Stroobant; A Johnsson; A Wasteson; B Westermark; C H Heldin; J S Huang; T F Deuel
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Nature     Volume:  304     ISSN:  0028-0836     ISO Abbreviation:  Nature     Publication Date:    1983 Jul 7-13
Date Detail:
Created Date:  1983-08-11     Completed Date:  1983-08-11     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0410462     Medline TA:  Nature     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  35-9     Citation Subset:  IM; X    
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Animals
Cell Transformation, Neoplastic*
Genes*
Genes, Viral*
Growth Substances / genetics*,  isolation & purification
Humans
Macromolecular Substances
Molecular Weight
Nucleic Acid Hybridization
Oncogene Proteins v-sis
Oncogenes*
Peptides / genetics*,  isolation & purification
Platelet-Derived Growth Factor
RNA, Messenger / genetics
Retroviridae / genetics*
Sarcoma Virus, Woolly Monkey / genetics*
Viral Proteins / genetics*
Grant Support
ID/Acronym/Agency:
CA22409/CA/NCI NIH HHS; HL14147/HL/NHLBI NIH HHS; HL22119/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Growth Substances; 0/Macromolecular Substances; 0/Oncogene Proteins v-sis; 0/Peptides; 0/Platelet-Derived Growth Factor; 0/RNA, Messenger; 0/Viral Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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