Document Detail


Platelet-derived growth factor signaling in mesenchymal cells.
MedLine Citation:
PMID:  23276912     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Platelet-derived growth factors (PDGFs) and their receptors are major mitogens for many cell types of mensenchymal origin, including fibroblasts and vascular smooth muscle cells (VSMCs). Their role in enhancing migratory and proliferative responses and extracellular matrix synthesis in these cells, make them key regulators of critical biological functions and in tissue diseases including tissue remodeling, scarring and fibrosis. The activities of the PDGFs have been extensively characterized at the molecular and cellular level and in in vivo model systems. This, in turn, has lead to an increasing number of PDGF-based therapies designed to accelerate or combat defects in tissue repair. This review aims to summarize recent developments in the role of PDGF in key mesenchymal cell functions. Many of the current developments in this field have primarily focused on advancements in understanding cell differentiation, migration, proliferation and the development of emerging PDGF-based therapies and hence will be primary focus of this review.
Authors:
Johanna Donovan; David Abraham; Jill Norman
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2013-01-01
Journal Detail:
Title:  Frontiers in bioscience (Landmark edition)     Volume:  18     ISSN:  1093-4715     ISO Abbreviation:  Front Biosci (Landmark Ed)     Publication Date:  2013  
Date Detail:
Created Date:  2013-01-01     Completed Date:  2013-06-12     Revised Date:  2013-07-29    
Medline Journal Info:
Nlm Unique ID:  101612996     Medline TA:  Front Biosci (Landmark Ed)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  106-19     Citation Subset:  IM    
Affiliation:
UCL Medical School, Royal Free Campus, Centre for Rheumatology & Connective Tissue Diseases, Rowland Hill Street, London. johanna.donovan@ucl.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Animals
Bone Remodeling / physiology
Cell Movement / physiology
Cell Proliferation
Fibroblasts / physiology
Humans
Integrins / metabolism
Ligands
Mesenchymal Stromal Cells / physiology
Platelet-Derived Growth Factor / biosynthesis,  physiology*,  therapeutic use
Protein Multimerization
Proto-Oncogene Proteins c-sis / metabolism
Receptors, Platelet-Derived Growth Factor / chemistry,  physiology
Signal Transduction / physiology*
Wound Healing / physiology
Grant Support
ID/Acronym/Agency:
16379//Arthritis Research UK; 18420//Arthritis Research UK; 19427//Arthritis Research UK
Chemical
Reg. No./Substance:
0/Integrins; 0/Ligands; 0/Platelet-Derived Growth Factor; 0/Proto-Oncogene Proteins c-sis; 0/platelet-derived growth factor A; 0/platelet-derived growth factor BB; EC 2.7.10.1/Receptors, Platelet-Derived Growth Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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