| Platelet depletion in experimental myocardial infarction. | |
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MedLine Citation:
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PMID: 4026785 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Accumulation of platelets in the microvasculature after acute myocardial ischemia may exacerbate tissue injury through the formation of microthrombi and by the release of vasoactive substances. To assess the role of platelets in myocardial ischemic injury and infarction, circulating platelets were reduced by 94 +/- 2% (mean +/- S.E.M.) with sheep antiserum to canine platelets. Regional myocardial ischemia was produced by occlusion of the left circumflex coronary artery (LCCA) for 90 min followed by reperfusion for 5 hours. Infarct size did not differ significantly between antiplatelet serum and nonimmune serum groups: 36 +/- 8 vs. 43 +/- 4% of the area at risk, determined by a post-mortem dual staining technique (p greater than 0.05). A second occlusion-reperfusion control group, sacrificed at 24 hours, did not differ from 5 hr reperfused groups with regard to infarct size. Coronary sinus thromboxane B2 (TXB2) concentrations were not altered significantly by platelet depletion. Histopathologic examination confirmed the presence of necrosis in the infarcted myocardium and revealed substantial leukocytic infiltration in both groups. The results suggest that circulating platelets are not required for the full expression of myocardial ischemic injury resulting from temporary coronary artery occlusion followed by reperfusion. |
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Authors:
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S R Jolly; W A Schumacher; S L Kunkel; G D Abrams; J Liddicoat; B R Lucchesi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Basic research in cardiology Volume: 80 ISSN: 0300-8428 ISO Abbreviation: Basic Res. Cardiol. Publication Date: 1985 May-Jun |
Date Detail:
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Created Date: 1985-09-16 Completed Date: 1985-09-16 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0360342 Medline TA: Basic Res Cardiol Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 269-79 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Dogs Hemodynamics Male Myocardial Infarction / blood*, pathology Myocardium / pathology Platelet Aggregation* Platelet Count* Thromboxane A2 / metabolism Thromboxane B2 / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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HL-19782/HL/NHLBI NIH HHS; HL-27817/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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54397-85-2/Thromboxane B2; 57576-52-0/Thromboxane A2 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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