Document Detail

Platelet count may predict abnormal bleeding time among pregnant women with hypertension and preeclampsia.
MedLine Citation:
PMID:  11444451     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Anesthesiologists often require laboratory data to estimate the bleeding risk among hypertensive pregnant women prior to administering regional anesthesia. Many rely on the bleeding time (BT) in making this determination. We examined whether the platelet count can adequately predict BT among a group of hypertensive parturients. METHODS: This retrospective subgroup analysis, taken from a cohort of 2,051 hypertensive pregnant women, comprises 87 individuals who underwent both a BT and platelet count prior to delivery. We calculated the correlation between the platelet count and BT at three platelet cut-off points with respect to prolonged BT of eight minutes or more. RESULTS: There was a significant negative correlation between platelet count at delivery and BT [r= -0.45, 95% confidence interval (CI) -0.26 to -0.60; P <0.0001]. All three platelet cut-off points had a sensitivity of less than 66% with negative predictive values below 75% for an abnormal BT. A platelet count > or =75 x 109/L [corrected] was specific for the presence of an abnormal BT (specificity 97.8%, 95% CI 91.7-100.0), with a positive predictive value of 95.5% (95% CI 83.1-100.0) and a positive likelihood ratio of 24 (95% CI 3.3-168). CONCLUSIONS: In a group of hypertensive parturients, the platelet count appears to be very specific for predicting a prolonged BT The platelet count may aid the anesthesiologist in determining the risk of bleeding from regional anesthesia. Given the study's potential for bias future research is needed to validate these findings.
R J McDonagh; J G Ray; R F Burrows; E A Burrows; M J Vermeulen
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Canadian journal of anaesthesia = Journal canadien d'anesthésie     Volume:  48     ISSN:  0832-610X     ISO Abbreviation:  Can J Anaesth     Publication Date:  2001 Jun 
Date Detail:
Created Date:  2001-07-10     Completed Date:  2001-12-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8701709     Medline TA:  Can J Anaesth     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  563-9     Citation Subset:  IM    
Department of Obstetrics and Gynecology, St Joseph's Hospital and McMaster University, Hamilton, Ontario, Canada.
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MeSH Terms
Bleeding Time*
Hypertension / blood,  complications*
Infant, Newborn
Platelet Count*
Pre-Eclampsia / blood,  complications*
Predictive Value of Tests
Pregnancy Complications, Hematologic / therapy*
Retrospective Studies
Comment In:
Can J Anaesth. 2001 Jun;48(6):515-8   [PMID:  11444442 ]
Erratum In:
Can J Anaesth 2002 Apr;49(4):437

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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