| Platelet collagen receptor GPIa (C807T/HPA-5) haplotype is not associated with an increased risk of fatal coronary events in middle-aged men. | |
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MedLine Citation:
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PMID: 12208476 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Platelet GPIa/IIa receptors play key roles in the adhesion of platelets to collagen during the formation of coronary thrombosis. The C807T and HPA-5 polymorphisms of the gene for GPIa define three distinct alleles of GPIa which are associated with the surface expression of the protein in an allele-dependent fashion. Significance of these polymorphisms in victims of sudden cardiac death (SCD) was studied in Helsinki Sudden Death Study (HSDS) comprising 700 autopsied middle-aged Caucasian Finnish men with 288 SCD victims and 84 men with fatal acute myocardial infarction (AMI). The high-expression A1 allele was found in 36.6% of control men as opposed to 38.0% of all SCD victims and 36.9% of men with fatal AMI (P>0.4). The high-expression A1A1 genotype was found in 11.9% of men with fatal AMI and 10.0% of controls as opposed to the low-expression A2A2 genotype which was found in 29.8% of men with fatal AMI and in 31.2% of controls (OR 1.2, P>0.3). Age group (under/over 55) had no effect on the results. Our results do not support an effect of the GPIa haplotype on fatal coronary events among middle-aged men. |
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Authors:
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Jussi Mikkelsson; Markus Perola; Antti Penttilä; Pekka J Karhunen |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Atherosclerosis Volume: 165 ISSN: 0021-9150 ISO Abbreviation: Atherosclerosis Publication Date: 2002 Nov |
Date Detail:
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Created Date: 2002-09-04 Completed Date: 2002-12-06 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0242543 Medline TA: Atherosclerosis Country: Ireland |
Other Details:
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Languages: eng Pagination: 111-8 Citation Subset: IM |
Affiliation:
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Medical School/building B, University of Tampere and Tampere University Hospital, P.O. Box 607, FIN-33014 Tampere, Finland. jm56215@uta.fi |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Analysis of Variance Autopsy Coronary Thrombosis / genetics*, mortality*, pathology Death, Sudden, Cardiac* Finland / epidemiology Gene Expression Regulation Haplotypes Humans Male Middle Aged Myocardial Infarction / genetics*, mortality*, pathology Platelet Glycoprotein GPIb-IX Complex / genetics* Polymorphism, Genetic* Probability Prospective Studies Risk Assessment Risk Factors Sampling Studies |
| Chemical | |
Reg. No./Substance:
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0/Platelet Glycoprotein GPIb-IX Complex |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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