Document Detail


Platelet c-mpl expression is dysregulated in patients with essential thrombocythaemia but this is not of diagnostic value.
MedLine Citation:
PMID:  10520034     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Essential thrombocythaemia (ET) can be difficult to discriminate from an occult case of reactive thrombocytosis (RT). Since thrombopoietin (TPO) is the primary regulator of thrombopoiesis, we have investigated whether levels of TPO and/or its receptor, c-mpl, are of value in the differential diagnosis of ET. Plasma TPO levels in patients with ET, RT and other myeloproliferative disorders (MPDs) did not differ significantly from normal controls. However, surface c-mpl expression was significantly reduced in platelets from 18 ET patients, 0-65.5% of controls (P < 0.001). Immunoblots on five of these and five additional patients were consistent with absent or reduced c-mpl protein levels. The surface c-mpl expression results were significantly different from those in eight RT patients (21. 3-95.5%, P = 0.0015), but there was considerable overlap between the two groups and a reduced level was not restricted to ET. Furthermore, c-mpl expression in ET patients was not different from eight patients with other MPDs (0-87.6%, P = 0.06), nor could it differentiate between ET patients with monoclonal and polyclonal haemopoiesis. Although a low or absent c-mpl level is suggestive of a primary rather than a secondary thrombocytosis, it is insufficiently discriminatory to be used as a diagnostic marker for ET.
Authors:
C N Harrison; R E Gale; F Pezella; A Mire-Sluis; S J MacHin; D C Linch
Related Documents :
18046434 - Effect of angiotensin-converting enzyme inhibitors on systemic inflammation and myocard...
8809134 - Production of il-5 and il-6 by peripheral blood mononuclear cells (pbmc) from patients ...
14587304 - The effects of haemodialysis and peritoneal dialysis on serum lipoprotein(a) and c-reac...
1284544 - Observations on the interleukin-6 and acute phase protein profiles in the disease cours...
25439364 - Prediction of airway inflammation in patients with asymptomatic asthma by using lung so...
24661374 - Zinc monotherapy is effective in wilson's disease patients with mild liver disease diag...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of haematology     Volume:  107     ISSN:  0007-1048     ISO Abbreviation:  Br. J. Haematol.     Publication Date:  1999 Oct 
Date Detail:
Created Date:  1999-11-30     Completed Date:  1999-11-30     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0372544     Medline TA:  Br J Haematol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  139-47     Citation Subset:  IM    
Affiliation:
Department of Haematology, University College London. c.harrison@ucl.ac.uk
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Blood Platelets / metabolism*
Blotting, Western
Bone Marrow / pathology
Female
Humans
Immunohistochemistry
Male
Platelet Count
Thrombocythemia, Essential / blood,  diagnosis*
Thrombopoietin / metabolism*
Chemical
Reg. No./Substance:
9014-42-0/Thrombopoietin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Serum interleukin-6 has no discriminatory role in paraproteinaemia nor a prognostic role in multiple...
Next Document:  The PNH phenotype cells that emerge in most patients after CAMPATH-1H therapy are present prior to t...