Document Detail

Platelet, antithrombin, and fibrinolytic activities in taurine-deficient and taurine-replete cats.
MedLine Citation:
PMID:  8214889     Owner:  NLM     Status:  MEDLINE    
Cats with cardiomyopathy, especially dilated cardiomyopathy associated with taurine deficiency, often develop systemic thrombi. To investigate the relation of taurine deficiency to formation and persistence of thrombi, cats were made taurine-deficient by consumption of a casein-based taurine-deficient diet, then were evaluated for anticoagulant and profibrinolytic activities and platelet function. The cats served as their own controls in the taurine-replete state; then, values were compared for the taurine-deficient state. Plasma (P < 0.01), blood (P < 0.05), and platelet (P < 0.05) taurine concentrations were decreased markedly after cats consumed the taurine-deficient diet for 6 weeks, compared with baseline concentrations before diet. Compared with the taurine-replete state, taurine deficiency induced significantly (P < 0.05) increased mean antithrombin III activity, no significant change in plasminogen and fibrinolytic activities, and similar clot retraction/lysis test results. Decreased (P < 0.01) adenosine diphosphate (ADP)-induced platelet aggregation and [14C]serotonin release, and slightly increased (P < 0.05) collagen-induced platelet [14C]serotonin release, but unchanged collagen-induced platelet aggregation were observed in taurine-deficient cats, compared with taurine-replete cats. Changes in antithrombin III activity most likely reflected hepatocellular acute-phase reaction, which indicates that taurine deficiency may induce a stress-responsive state. Results of platelet function testing indicate that taurine may modulate platelet responsiveness to physiologic agonists, but not in consistent manner. That platelets from the taurine-deficient cats had decreased responsiveness to ADP, but increased responsiveness to collagen is surprising, because irreversible aggregation is mediated by release of granule-associated ADP after sufficient initial stimulus.(ABSTRACT TRUNCATED AT 250 WORDS)
E G Welles; M K Boudreaux; J W Tyler
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of veterinary research     Volume:  54     ISSN:  0002-9645     ISO Abbreviation:  Am. J. Vet. Res.     Publication Date:  1993 Aug 
Date Detail:
Created Date:  1993-11-04     Completed Date:  1993-11-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375011     Medline TA:  Am J Vet Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1235-43     Citation Subset:  IM    
Department of Pathobiology, College of Veterinary Medicine, Auburn University, AL 36849-5519.
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MeSH Terms
Adenosine Diphosphate / diagnostic use
Antithrombins / metabolism
Blood Platelets / physiology*
Cat Diseases / blood*
Collagen / diagnostic use
Fibrinolysis / physiology*
Plasminogen / metabolism
Platelet Aggregation / physiology
Taurine / deficiency*
Thrombosis / blood,  veterinary*
Reg. No./Substance:
0/Antithrombins; 107-35-7/Taurine; 58-64-0/Adenosine Diphosphate; 9001-91-6/Plasminogen; 9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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