Document Detail


Platelet, antithrombin, and fibrinolytic activities in taurine-deficient and taurine-replete cats.
MedLine Citation:
PMID:  8214889     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cats with cardiomyopathy, especially dilated cardiomyopathy associated with taurine deficiency, often develop systemic thrombi. To investigate the relation of taurine deficiency to formation and persistence of thrombi, cats were made taurine-deficient by consumption of a casein-based taurine-deficient diet, then were evaluated for anticoagulant and profibrinolytic activities and platelet function. The cats served as their own controls in the taurine-replete state; then, values were compared for the taurine-deficient state. Plasma (P < 0.01), blood (P < 0.05), and platelet (P < 0.05) taurine concentrations were decreased markedly after cats consumed the taurine-deficient diet for 6 weeks, compared with baseline concentrations before diet. Compared with the taurine-replete state, taurine deficiency induced significantly (P < 0.05) increased mean antithrombin III activity, no significant change in plasminogen and fibrinolytic activities, and similar clot retraction/lysis test results. Decreased (P < 0.01) adenosine diphosphate (ADP)-induced platelet aggregation and [14C]serotonin release, and slightly increased (P < 0.05) collagen-induced platelet [14C]serotonin release, but unchanged collagen-induced platelet aggregation were observed in taurine-deficient cats, compared with taurine-replete cats. Changes in antithrombin III activity most likely reflected hepatocellular acute-phase reaction, which indicates that taurine deficiency may induce a stress-responsive state. Results of platelet function testing indicate that taurine may modulate platelet responsiveness to physiologic agonists, but not in consistent manner. That platelets from the taurine-deficient cats had decreased responsiveness to ADP, but increased responsiveness to collagen is surprising, because irreversible aggregation is mediated by release of granule-associated ADP after sufficient initial stimulus.(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
E G Welles; M K Boudreaux; J W Tyler
Related Documents :
8930739 - Lidocaine and nisoldipine attenuate almokalant-induced dispersion of repolarization and...
21757059 - Mifepristone (ru 486) induces vasodilation and inhibits platelet aggregation: nongenomi...
717349 - Hemostatic alterations in inflammatory bowel disease: response to therapy.
12415589 - Connective tissue activation xxxviii: heparin/heparanase activity of human platelets re...
8214889 - Platelet, antithrombin, and fibrinolytic activities in taurine-deficient and taurine-re...
21932189 - Significant relationship between platelet activation and apnea-hypopnea index in patien...
878829 - Prostaglandin f2alpha as a mediator of pulmonary changes during platelet aggregation.
6470709 - N-acetyl-aspartyl-glutamate: regional levels in rat brain and the effects of brain lesi...
12439149 - A study of platelet activation in paroxysmal, persistent and permanent atrial fibrillat...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of veterinary research     Volume:  54     ISSN:  0002-9645     ISO Abbreviation:  Am. J. Vet. Res.     Publication Date:  1993 Aug 
Date Detail:
Created Date:  1993-11-04     Completed Date:  1993-11-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375011     Medline TA:  Am J Vet Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1235-43     Citation Subset:  IM    
Affiliation:
Department of Pathobiology, College of Veterinary Medicine, Auburn University, AL 36849-5519.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adenosine Diphosphate / diagnostic use
Animals
Antithrombins / metabolism
Blood Platelets / physiology*
Cat Diseases / blood*
Cats
Collagen / diagnostic use
Fibrinolysis / physiology*
Male
Plasminogen / metabolism
Platelet Aggregation / physiology
Taurine / deficiency*
Thrombosis / blood,  veterinary*
Chemical
Reg. No./Substance:
0/Antithrombins; 107-35-7/Taurine; 58-64-0/Adenosine Diphosphate; 9001-91-6/Plasminogen; 9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Hemostasis in cows with endotoxin-induced mastitis.
Next Document:  Variation of abscess formation in cattle after vaccination with a modified-live Pasteurella haemolyt...