| Platelet activation during exercise induced asthma: effect of prophylaxis with cromoglycate and salbutamol. | |
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MedLine Citation:
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PMID: 2943049 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Peak expiratory flow (PEF) and plasma concentrations of platelet factor 4 and beta thromboglobulin were measured before and after exercise in nine asthmatic patients and 12 non-asthmatic volunteers. Exercise was preceded by administration in random order of either placebo, salbutamol 200 micrograms, or sodium cromoglycate 2 mg from a pressurised inhaler. In control subjects there were minimal changes in PEF and plasma concentrations of platelet factor 4 and beta thromboglobulin. In the asthmatic patients the typical changes in PEF were seen on exercise; plasma concentrations of platelet factor 4 and beta thromboglobulin rose significantly in parallel, the rise preceding the fall in PEF. The changes in peak flow and platelet activation induced by exercise were attenuated by prior administration of salbutamol or cromoglycate. These results indicate that exercise induced asthma is associated with a rise in platelet release products similar to that observed in antigen induced asthma. |
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Authors:
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C E Johnson; P W Belfield; S Davis; N J Cooke; A Spencer; J A Davies |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Thorax Volume: 41 ISSN: 0040-6376 ISO Abbreviation: Thorax Publication Date: 1986 Apr |
Date Detail:
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Created Date: 1986-09-17 Completed Date: 1986-09-17 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0417353 Medline TA: Thorax Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 290-4 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Albuterol / therapeutic use* Asthma / physiopathology* Asthma, Exercise-Induced / blood, physiopathology*, prevention & control Blood Platelets / physiology* Cromolyn Sodium / therapeutic use* Humans Peak Expiratory Flow Rate Platelet Factor 4 / analysis beta-Thromboglobulin / analysis |
| Chemical | |
Reg. No./Substance:
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0/beta-Thromboglobulin; 15826-37-6/Cromolyn Sodium; 18559-94-9/Albuterol; 37270-94-3/Platelet Factor 4 |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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