Document Detail


Platelet-activating factor and its structural analogues in the earthworm Eisenia foetida.
MedLine Citation:
PMID:  7654776     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The earthworm Eisenia foetida was shown to contain large amounts of ether-containing phospholipids such as alkylacylglycerophosphocholine (61.3% of choline glycerophospholipids) and alkenylacylglycerophosphoethanolamine (66.0% of ethanolamine glycerophospholipids). We also found a substantial amount of ether-containing PAF-like lipid in this animal, its level being increased after the animal is injured. We showed evidence that this PAF-like lipid consists of PAF and PAF analogues containing short chain fatty acids other than acetic acid. Notably, a propionic acid-containing species but not PAF itself, is the most predominant species in this animal. We also confirmed that the earthworms contain enzyme activities involved in the synthesis of PAF and short chain fatty acid-containing PAF analogues. Interestingly, the acetyltransferase activity in earthworms is resistant to high concentrations of the substrate lysophospholipid. Thus, both the structure of the PAF-like lipid and the properties of the enzymes involved in the PAF-like lipid metabolism in the earthworms are somewhat different from those in mammalian tissues.
Authors:
T Sugiura; A Yamashita; N Kudo; T Fukuda; T Miyamoto; N N Cheng; S Kishimoto; K Waku; T Tanaka; H Tsukatani
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  1258     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  1995 Aug 
Date Detail:
Created Date:  1995-10-02     Completed Date:  1995-10-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  19-26     Citation Subset:  IM    
Affiliation:
Faculty of Pharmaceutical Services, Teikyo University, Kanagawa, Japan.
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MeSH Terms
Descriptor/Qualifier:
Acetyltransferases / metabolism
Animals
Gas Chromatography-Mass Spectrometry
Kinetics
Oligochaeta / chemistry*
Phosphatidylcholines / analysis
Phosphatidylethanolamines / analysis
Phospholipids / analysis
Platelet Activating Factor / analogs & derivatives,  analysis*
Species Specificity
Chemical
Reg. No./Substance:
0/Phosphatidylcholines; 0/Phosphatidylethanolamines; 0/Phospholipids; 0/Platelet Activating Factor; EC 2.3.1.-/Acetyltransferases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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