| Platelet-activating factor induces intestinal necrosis, but not septic shock, in germ-free and specific-pathogen-free rodents. | |
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MedLine Citation:
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PMID: 1834076 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Platelet-activating factor (PAF) was injected into conventional mice, endotoxin-resistant mice (C3H/HEJ), conventional rats, germ-free rats and specific-pathogen-free (SPF) mice. The PAF resulted in significant necrosis and damage to the small intestines of all the animals tested. In general, the frequency and severity of the lesions were similar in all groups. All the conventional rats and mice, as well as the endotoxin-resistant HEJ mice, were dead 18 h after the injection of the PAF, while all the germ-free rats and the SPF mice survived. These data demonstrate that development of massive intestinal lesions, in the absence of aerobic bacteria, is not sufficient to cause the death of the host from septic shock and endotoxaemia. |
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Authors:
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E J Schiffrin; M Trop; S Schroeder; E A Carter |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Burns : journal of the International Society for Burn Injuries Volume: 17 ISSN: 0305-4179 ISO Abbreviation: Burns Publication Date: 1991 Aug |
Date Detail:
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Created Date: 1991-12-09 Completed Date: 1991-12-09 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8913178 Medline TA: Burns Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 276-8 Citation Subset: IM |
Affiliation:
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Massachusetts General Hospital, Boston. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Female Germ-Free Life Intestine, Small / drug effects, pathology* Lipopolysaccharides Mice Mice, Inbred C3H Necrosis Platelet Activating Factor / toxicity* Rats Salmonella typhi Shock, Septic / etiology* Specific Pathogen-Free Organisms |
| Chemical | |
Reg. No./Substance:
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0/Lipopolysaccharides; 0/Platelet Activating Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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