Document Detail


Platelet-activating factor induces intestinal necrosis, but not septic shock, in germ-free and specific-pathogen-free rodents.
MedLine Citation:
PMID:  1834076     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Platelet-activating factor (PAF) was injected into conventional mice, endotoxin-resistant mice (C3H/HEJ), conventional rats, germ-free rats and specific-pathogen-free (SPF) mice. The PAF resulted in significant necrosis and damage to the small intestines of all the animals tested. In general, the frequency and severity of the lesions were similar in all groups. All the conventional rats and mice, as well as the endotoxin-resistant HEJ mice, were dead 18 h after the injection of the PAF, while all the germ-free rats and the SPF mice survived. These data demonstrate that development of massive intestinal lesions, in the absence of aerobic bacteria, is not sufficient to cause the death of the host from septic shock and endotoxaemia.
Authors:
E J Schiffrin; M Trop; S Schroeder; E A Carter
Related Documents :
20571906 - Lactobacillus plantarum prevents the development of colitis in il-10-deficient mouse by...
21870976 - Group of serum inflammatory markers and periodontitis-metabolic syndrome co-existence i...
16261526 - A kampo formula juzen-taiho-to induces expression of metallothioneins in mice.
21778416 - Endotoxin-induced cardiovascular dysfunction in mice: effect of simvastatin.
2521586 - Cellular interactions for the in vitro production of anti-chromatin autoantibodies in m...
24478096 - Myd88 signaling is directly involved in the development of murine placental malaria.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Burns : journal of the International Society for Burn Injuries     Volume:  17     ISSN:  0305-4179     ISO Abbreviation:  Burns     Publication Date:  1991 Aug 
Date Detail:
Created Date:  1991-12-09     Completed Date:  1991-12-09     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8913178     Medline TA:  Burns     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  276-8     Citation Subset:  IM    
Affiliation:
Massachusetts General Hospital, Boston.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Female
Germ-Free Life
Intestine, Small / drug effects,  pathology*
Lipopolysaccharides
Mice
Mice, Inbred C3H
Necrosis
Platelet Activating Factor / toxicity*
Rats
Salmonella typhi
Shock, Septic / etiology*
Specific Pathogen-Free Organisms
Chemical
Reg. No./Substance:
0/Lipopolysaccharides; 0/Platelet Activating Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The dopamine D2 receptor is expressed in GH3 cells.
Next Document:  Inhibition of mitochondrial respiratory function by an organic solvent extractable component from an...