Document Detail

Platelet-activating factor induces intestinal necrosis, but not septic shock, in germ-free and specific-pathogen-free rodents.
MedLine Citation:
PMID:  1834076     Owner:  NLM     Status:  MEDLINE    
Platelet-activating factor (PAF) was injected into conventional mice, endotoxin-resistant mice (C3H/HEJ), conventional rats, germ-free rats and specific-pathogen-free (SPF) mice. The PAF resulted in significant necrosis and damage to the small intestines of all the animals tested. In general, the frequency and severity of the lesions were similar in all groups. All the conventional rats and mice, as well as the endotoxin-resistant HEJ mice, were dead 18 h after the injection of the PAF, while all the germ-free rats and the SPF mice survived. These data demonstrate that development of massive intestinal lesions, in the absence of aerobic bacteria, is not sufficient to cause the death of the host from septic shock and endotoxaemia.
E J Schiffrin; M Trop; S Schroeder; E A Carter
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Burns : journal of the International Society for Burn Injuries     Volume:  17     ISSN:  0305-4179     ISO Abbreviation:  Burns     Publication Date:  1991 Aug 
Date Detail:
Created Date:  1991-12-09     Completed Date:  1991-12-09     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8913178     Medline TA:  Burns     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  276-8     Citation Subset:  IM    
Massachusetts General Hospital, Boston.
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MeSH Terms
Germ-Free Life
Intestine, Small / drug effects,  pathology*
Mice, Inbred C3H
Platelet Activating Factor / toxicity*
Salmonella typhi
Shock, Septic / etiology*
Specific Pathogen-Free Organisms
Reg. No./Substance:
0/Lipopolysaccharides; 0/Platelet Activating Factor

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