Document Detail

Platelet-activating factor enhanced the pressor response of endothelin-1.
MedLine Citation:
PMID:  12352314     Owner:  NLM     Status:  MEDLINE    
Both endothelin-1 (ET-1) and platelet-activating factor (PAF) have been suggested to play a role in the regulation of the cardiovascular system. In view of the limited data regarding the interaction between ET-1 and PAF, the hemodynamic effects of ET-1 and PAF, either alone or in combination, were investigated in the current study. Anesthetized male Sprague Dawley rats received bolus intravenous injections of ET-1 (1 and 2 nmol/kg) and/or PAF (0.075, 0.15 and 0.3 nmol/kg). In some experiments, the ET receptor antagonist, FR-139317 (2.5 or 5 mg/kg), were injected 5 min before the administration of ET-1 or PAF. ET-1 caused a biphasic response consisting of an initial depressor followed by a delayed but sustained pressor response. Injection of PAF to anesthetized rats resulted only in a decrease in arterial blood pressure. Interestingly, the pressor effect of ET-1 was significantly enhanced in the concomitant presence of PAF. Pretreatment with FR-139317 inhibited the magnitude of ET-1-induced hypertension and increased the duration of the depressor action of ET-1. The time-course of PAF-induced decrease of arterial blood pressure was also prolonged in rats pretreated with FR-139317. These data therefore suggested that ET receptors were activated, either directly or indirectly, by PAF, possibly to facilitate the return of blood pressure to resting level following a depressor response. Thus the activation of ET receptors by PAF might result in the enhancement of the pressor response of ET-1 observed in the current study.
Susan W S Leung; Godfrey S K Man; Ricky Y K Man
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  40     ISSN:  0160-2446     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2002-09-27     Completed Date:  2003-03-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  528-32     Citation Subset:  IM    
Department of Pharmacology, Faculty of Medicine, University of Hong Kong, Hong Kong SAR, China.
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MeSH Terms
Blood Pressure / drug effects*,  physiology
Drug Synergism
Endothelin-1 / pharmacology*,  physiology
Platelet Activating Factor / pharmacology*,  physiology
Rats, Sprague-Dawley
Receptor, Endothelin A
Receptors, Endothelin / antagonists & inhibitors,  physiology
Reg. No./Substance:
0/Endothelin-1; 0/Platelet Activating Factor; 0/Receptor, Endothelin A; 0/Receptors, Endothelin

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