Document Detail

Platelet-activating factor does not mediate circulatory failure induced by 35-GHz microwave heating.
MedLine Citation:
PMID:  12168504     Owner:  NLM     Status:  MEDLINE    
Sustained whole-body exposure of anesthetized rats to 35-GHz radiofrequency radiation produces localized hyperthermia and hypotension, leading to circulatory failure and death. The physiological mechanism underlying the induction of circulatory failure by 35-GHz microwave (MW) heating is currently unknown. The purpose of this study was to determine whether platelet-activating factor (PAF) contributes to the hypotensive state induced by MW heating. Ketamine-anesthetized rats were instrumented for the measurement of arterial blood pressure, ECG and temperature at five sites. Administration of the PAF-receptor antagonist WEB 2086 (0.5 or 5 mg/kg) following the induction of circulatory failure (defined as a decrease in mean arterial blood pressure to 75 mmHg) failed to reverse the hypotension induced by MW heating and consequently did not alter the subsequent survival time. Furthermore, pretreatment with WEB 2086 at either dose did not alter subsequent mean arterial blood pressure, temperature responses to MW heating or survival time. Finally, MW heating did not alter either blood PAF levels or serum or lung PAF acetylhydrolase levels. Taken together, these results demonstrate that PAF does not mediate the hypotension induced by 35-GHz MW heating.
K L Ryan; J R Jauchem; M R Tehrany; H L Boyle
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Methods and findings in experimental and clinical pharmacology     Volume:  24     ISSN:  0379-0355     ISO Abbreviation:  Methods Find Exp Clin Pharmacol     Publication Date:  2002 Jun 
Date Detail:
Created Date:  2002-08-09     Completed Date:  2003-01-07     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7909595     Medline TA:  Methods Find Exp Clin Pharmacol     Country:  Spain    
Other Details:
Languages:  eng     Pagination:  279-86     Citation Subset:  IM    
Air Force Research Laboratory, Directed Energy Bioeffects Division, Radio Frequency Radiation Branch, Brooks Air Force Base, San Antonio, Texas, USA.
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MeSH Terms
Azepines / pharmacology
Fever / etiology*,  prevention & control
Hemodynamics / drug effects
Hypotension / etiology*
Microwaves / adverse effects*
Platelet Activating Factor / antagonists & inhibitors,  metabolism,  physiology*
Rats, Sprague-Dawley
Triazoles / pharmacology
Reg. No./Substance:
0/Azepines; 0/Platelet Activating Factor; 0/Triazoles; 105219-56-5/WEB 2086

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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