Document Detail

Platelet glycoprotein IIb HPA-3 a/b polymorphism is associated with native arteriovenous fistula thrombosis in chronic hemodialysis patients.
MedLine Citation:
PMID:  22880801     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The aim of this study was to investigate the association of Glycoprotein IIb (GPIIb) human platelet antigen-3 (HPA-3) a/b polymorphism with end-stage renal disease (ESRD) on hemodialysis (HD) and native Arteriovenous fistula (AVF) thrombosis.
METHODS: The polymorphism in the GPIIb subunit of the receptor HPA-3 (a and b alleles) was identified by polymerase chain reaction with sequence-specific primers (PCR-SSP) in 145 HD patients and 120 healthy controls from a Chinese Han population. The HD patients were classified into two groups: G1 and G2. G1 included 65 HD patients presented at least one AVF thrombosis episode and G2 included 80 HD patients without any episode of AVF thrombosis.
RESULTS: There were no significant differences in either HPA-3 a/b genotypes (aa, ab, and bb) frequency distribution (p = 0.396) or allele (a and b) frequency distribution (p = 0.146) between HD patients and control groups. However, there were significant differences in both HPA-3 a/b genotypes (aa, ab, and bb) distribution (χ(2) = 6.127, p = 0.047) and allele (a and b) frequency distribution (χ(2) = 5.954, p = 0.015) between G1 and G2. The relative risk of native AVF dysfunction in ab + bb patients compared with that of aa patients was 2.31 (95% confidence interval: 1.18-4.52).
CONCLUSIONS: These findings suggest an association between AVF thrombosis and the HPA-3b allele, and it is likely that HPA-3 a/b polymorphisms could be useful markers for potential risk of native AVF thrombosis in HD patients.
Jian-Hua Wu; Ding-Wu Zhang; Xiao-Lan Cheng; Hui Shi; Ya-Ping Fan
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Renal failure     Volume:  34     ISSN:  1525-6049     ISO Abbreviation:  Ren Fail     Publication Date:  2012  
Date Detail:
Created Date:  2012-08-13     Completed Date:  2013-06-12     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  8701128     Medline TA:  Ren Fail     Country:  England    
Other Details:
Languages:  eng     Pagination:  960-3     Citation Subset:  IM    
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MeSH Terms
Arteriovenous Shunt, Surgical*
Kidney Failure, Chronic / genetics*,  therapy
Middle Aged
Platelet Membrane Glycoprotein IIb / genetics*
Polymorphism, Genetic*
Renal Dialysis / adverse effects*
Risk Factors
Thrombosis / etiology,  genetics*
Reg. No./Substance:
0/Platelet Membrane Glycoprotein IIb

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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