Document Detail


Plateau phase in multiple myeloma: an analysis of long-term follow-up of 432 patients. Finnish Leukaemia Group.
MedLine Citation:
PMID:  8616075     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
DAta from an 8-year follow-up of 432 myeloma patients were analysed for incidence, duration and prognostic value of plateau phase and factors favouring its achievement. The first-line chemotherapy was melphalan and prednisolone in 121 cases, combination chemotherapy in 311 cases. The survival times were similar despite different response rates. Any response resulted in survival significantly (P<0.001) better than in patients with progressive disease, but the level of response had no influence in this respect. A plateau of at least 3 months was achieved in 81%, at least 6 months in 74%, at least 12 months in 59% and at least 24 months in 33%. Groups with significantly different (P<0.001) survivals were identified: a plateau of <3 months, 3-11 months, 12-23 months, and 24 months or longer, with median survivals of 10, 27, 46 and 81 months, respectively. In the multivariate analysis of pretreatment variables, only haemoglobin (Hb) (P<0.001) and creatinine at 2 months (P<0.01) were significant for a plateau >12 months. After inclusion of chemotherapy data, Hb and time taken to reach the best response were still significant (P=0.002). The predictive power of high Hb and slow response for achieving a plateau of 6 or 12 months was 79%. Accordingly, the criteria for response of treatment for multiple myeloma should include a stable period of at least 3 months; the criteria for a plateau a stable period of at least 12 months in order to have real prognostic significance.
Authors:
T M Oivanen
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Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of haematology     Volume:  92     ISSN:  0007-1048     ISO Abbreviation:  Br. J. Haematol.     Publication Date:  1996 Mar 
Date Detail:
Created Date:  1996-06-12     Completed Date:  1996-06-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372544     Medline TA:  Br J Haematol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  834-9     Citation Subset:  IM    
Affiliation:
Finnish Leukaemia Group, Department of Oncology, Tampere University Hospital, Finland.
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MeSH Terms
Descriptor/Qualifier:
Female
Follow-Up Studies
Humans
Male
Multiple Myeloma / drug therapy*
Prognosis
Prospective Studies
Survival Analysis
Survival Rate
Treatment Outcome

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