Document Detail

Plateau in muscle blood flow during prolonged exercise in miniature swine.
MedLine Citation:
PMID:  2745279     Owner:  NLM     Status:  MEDLINE    
Cardiovascular, metabolic, and thermoregulatory responses were studied in eight male miniature swine during a prolonged treadmill run. Each animal underwent 8-10 wk of exercise training, thoracic surgery, and 3 wk of retraining before the experimental run. This regimen enabled the animals to run at 65% of the heart rate range (210-220 beats/min) for approximately 100 min. Skin wetting and a fan were used to cool the pigs during the run. Regional blood flow was significantly altered with the onset of exercise; however, hindlimb muscle and total gastrointestinal blood flow were unchanged throughout the exercise period. Compared with 5-min values, heart rate and cardiac output were significantly elevated by 17 beats/min and 31 at 60 min and by 20 beats/min and 33 at end exercise, respectively. Core temperatures increased between 5 and 30 min of exercise (39.4 vs. 39.9 degrees C) but then remained unchanged to the end of exercise. Mean arterial pressure, O2 consumption, and blood lactate did not change during the exercise bout. These data indicate that limiting increases in core temperature during prolonged exercise was associated with a plateau in active muscle blood flow.
M D McKirnan; C G Gray; F C White
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  66     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1989 May 
Date Detail:
Created Date:  1989-08-25     Completed Date:  1989-08-25     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2101-8     Citation Subset:  IM; S    
Department of Pathology, School of Medicine, University of California, San Diego, La Jolla 92093.
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MeSH Terms
Blood Pressure
Body Temperature
Cardiac Output
Heart Rate
Muscles / blood supply*
Oxygen Consumption
Physical Exertion*
Regional Blood Flow
Swine, Miniature
Vascular Resistance

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