Document Detail

Plasticizers, infant nutrition and reproductive health.
MedLine Citation:
PMID:  15336709     Owner:  NLM     Status:  MEDLINE    
Since the 1930s, plasticizers have been used to impart flexibility to an otherwise rigid polyvinylchloride (PVC). Di-(2-ethylhexyl)-phthalate (DEHP) is the most widely used plasticizer in PVC formulations. However, DEHP leaks out from PVC items with time and use and consequently it is an ubiquitous environmental contaminant. To date, very little is known about the actual extent of DEHP exposure in infants, who are believed to be the most sensitive population, as they may be exposed to several different sources (breast milk, infant formula, baby food, indoor air, and by dermal and oral exposure via indoor dust containing DEHP) since early in life and since differences in DEHP pharmacokinetics and metabolism between children and adults have been well documented. Little information exists on DEHP dietary exposure, believed to represent a major source and orally administered DEHP is converted more rapidly to MEHP than other routes of exposure. Although DEHP has been shown to induce toxicity in experimental animals, a limited but suggestive human exposure data causes a serious concern that an early in life DEHP exposure may adversely affect male reproductive tract development. Here, we report a review on dietary phthalate exposure in babies.
Giuseppe Latini; Claudio De Felice; Alberto Verrotti
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Reproductive toxicology (Elmsford, N.Y.)     Volume:  19     ISSN:  0890-6238     ISO Abbreviation:  Reprod. Toxicol.     Publication Date:  2004 Nov 
Date Detail:
Created Date:  2004-08-31     Completed Date:  2005-04-28     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8803591     Medline TA:  Reprod Toxicol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  27-33     Citation Subset:  IM    
Division of Neonatology, Ospedale A. Perrino, S.S. 7 per Mesagne, 72100 Brindisi, Italy.
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MeSH Terms
Diethylhexyl Phthalate / analysis,  metabolism,  toxicity*
Environmental Exposure / adverse effects*
Environmental Monitoring
Environmental Pollutants / analysis,  metabolism,  toxicity*
Genitalia, Male / drug effects
Infant Formula / chemistry
Infant Nutritional Physiological Phenomena*
Infant, Newborn
Milk, Human / chemistry
Reproduction / drug effects*
Risk Assessment
Reg. No./Substance:
0/Environmental Pollutants; 117-81-7/Diethylhexyl Phthalate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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