Document Detail

Plasticity of rat small intestine after removal of a chronic mechanical obstruction.
MedLine Citation:
PMID:  16918766     Owner:  NLM     Status:  MEDLINE    
Chronic intestinal obstruction is associated with morphological changes and functional disorders clinically reported and experimentally documented in laboratory animals. In contrast, little is known about the properties of the hypertrophied intestine after removal of the obstruction. In the present study, we removed the ileal obstruction previously applied to the ileum of rats and, after 1 or 2 weeks, studied in vitro the motor responses of de-obstructed segments of intestine to pharmacological or electrical field stimulation (EFS). By 2 weeks after de-obstruction, maximal contractile responses to receptor (acetylcholine) and non-receptor (K(+)) mediated stimuli were comparable in operated and control tissues; furthermore, the loss of sensitivity to nitric oxide (NO) unmasked in obstructed tissues was, after de-obstruction, replaced by supersensitivity to exogenous NO and vasoactive intestinal polypeptide, probably acting through cyclic nucleotide-independent pathways. Despite the complete recovery of smooth muscle responses, neurogenic contractions remained impaired in de-obstructed tissue; however, the equal contribution of cholinergic/peptidergic components to EFS responses could represent a sign of gradual but delayed recovery of enteric neurotransmission.
S Bertoni; G Gabella; V Ballabeni; A Ghirardi; M Impicciatore; E Barocelli
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society     Volume:  18     ISSN:  1350-1925     ISO Abbreviation:  Neurogastroenterol. Motil.     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-08-21     Completed Date:  2006-10-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9432572     Medline TA:  Neurogastroenterol Motil     Country:  England    
Other Details:
Languages:  eng     Pagination:  862-72     Citation Subset:  IM    
Department of Pharmacological, Biological and Applied Chemical Sciences, University of Parma, Parma, Italy.
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MeSH Terms
Electric Stimulation
Gastrointestinal Motility / physiology*
Intestinal Obstruction / physiopathology*
Intestine, Small / physiopathology*
Muscle Contraction / physiology
Muscle, Smooth / physiopathology
Rats, Wistar
Recovery of Function / physiology*

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