| Plasticity and neural stem cells in the enteric nervous system. | |
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MedLine Citation:
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PMID: 19943347 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The enteric nervous system (ENS) is a highly organized part of the autonomic nervous system, which innervates the whole gastrointestinal tract by several interconnected neuronal networks. The ENS changes during development and keeps throughout its lifespan a significant capacity to adapt to microenvironmental influences, be it in inflammatory bowel diseases or changing dietary habits. The presence of neural stem cells in the pre-, postnatal, and adult gut might be one of the prerequisites to adapt to changing conditions. During the last decade, the ENS has increasingly come into the focus of clinical neural stem cell research, forming a considerable pool of neural crest derived stem cells, which could be used for cell therapy of dysganglionosis, that is, diseases based on the deficient or insufficient colonization of the gut by neural crest derived stem cells; in addition, the ENS could be an easily accessible neural stem cell source for cell replacement therapies for neurodegenerative disorders or traumatic lesions of the central nervous system. |
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Authors:
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Karl-Herbert Sch?fer; Chris Van Ginneken; Sjef Copray |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Anatomical record (Hoboken, N.J. : 2007) Volume: 292 ISSN: 1932-8494 ISO Abbreviation: Anat Rec (Hoboken) Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-12-03 Completed Date: 2010-02-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101292775 Medline TA: Anat Rec (Hoboken) Country: United States |
Other Details:
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Languages: eng Pagination: 1940-52 Citation Subset: IM |
Copyright Information:
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(c) 2009 Wiley-Liss, Inc. |
Affiliation:
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Department of Biotechnology, University of Applied Sciences Kaiserslautern, Amerikastrasse 1, Zweibr?cken, Germany. karl-herbert.schaefer@fh-kl.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Differentiation / physiology Enteric Nervous System / cytology*, embryology, physiology* Gastrointestinal Diseases / physiopathology Humans Nerve Net / cytology, embryology, physiology Neural Crest / cytology, embryology, physiology Neuronal Plasticity / physiology* Neurons / cytology, physiology Stem Cell Transplantation / methods Stem Cells / cytology*, physiology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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