Document Detail


Plastic changes in ipsi-contralateral differences of auditory cortex and inferior colliculus evoked potentials after injury to one ear in the adult guinea pig.
MedLine Citation:
PMID:  8150729     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In normal adult guinea pigs, evoked potentials recorded at the ipsilateral auditory cortex to monaural high-frequency acoustic stimuli present higher thresholds and lower amplitudes than at the contralateral cortex; in the inferior colliculus, such ipsi-contralateral differences (ICDs) are smaller than in the auditory cortex. Changes in the ICDs were studied after opposite ear injury. Following quasi-complete hair cell destruction induced by sisomicin injection into the contralateral inner ear, threshold ICDs almost disappeared after about two to six days and ipsilateral amplitudes progressively increased in two to three weeks. The occurrence of ICDs at higher auditory centers revealed in this study, indicates peculiar processing of high frequency stimuli in normal guinea pigs. The alteration of ICDs after opposite ear impairment provides a new possibility to study the auditory plasticity in adult animals.
Authors:
J Popelár; J P Erre; J M Aran; Y Cazals
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hearing research     Volume:  72     ISSN:  0378-5955     ISO Abbreviation:  Hear. Res.     Publication Date:  1994 Jan 
Date Detail:
Created Date:  1994-05-10     Completed Date:  1994-05-10     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7900445     Medline TA:  Hear Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  125-34     Citation Subset:  IM    
Affiliation:
Laboratoire d'Audiologie expérimentale, Inserm unité 229, Université Bordeaux II, France.
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MeSH Terms
Descriptor/Qualifier:
Acoustic Stimulation
Animals
Auditory Cortex / physiology*
Auditory Threshold / drug effects,  physiology
Electrodes, Implanted
Evoked Potentials, Auditory, Brain Stem / drug effects,  physiology*
Guinea Pigs
Hair Cells, Auditory / drug effects*
Inferior Colliculi / physiology*
Neuronal Plasticity / physiology*
Sisomicin / toxicity*
Chemical
Reg. No./Substance:
32385-11-8/Sisomicin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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