| Plasmonic Properties of Multispot Copper-Capped Nanoparticle Array Chip and Its Application to Optical Biosensor for Pathogen Detection of Multiplex DNAs. | |
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MedLine Citation:
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PMID: 21714496 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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A localized surface plasmon resonance (LSPR) based optical biosensor in connection with multispot copper-capped nanoparticle array (MC-NPA) chip was proposed and developed. The copper (Cu) films, used as shell, formed a "cap-like" layer on the top of the silica nanoparticles, used as core, in an orderly fashion, to form the surface called a "Cu-capped nanoparticle array chip". The plasmonic properties of this nanostructure type were initially investigated by controlling the shell thickness of the deposited Cu. Also, we quantified the sensitivity of MC-NPA chip to changes in bulk refractive index (RI). As a result of its LSPR properties, the function of RI displayed a sensitivity of 67.8 nm per RI unit and the wavelength shift of LSPR spectrum peak was sensitive to the RI of the surrounding bulk medium, such as biomolecular layers. Using MC-NPA chips, multiplex sensing of target DNAs from reference bacteria and clinical samples was possible in a quantitative manner with a detection limit of 10 fM (50 zmol). The optical biosensor developed in this study represents a unique approach to performing LSPR that utilizes a simple and cost effective optical setup with disposable chips. |
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Authors:
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Do-Kyun Kim; Seung Min Yoo; Tae Jung Park; Hiroyuki Yoshikawa; Eiichi Tamiya; Jung Youn Park; Sang Yup Lee |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-6-29 |
Journal Detail:
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Title: Analytical chemistry Volume: - ISSN: 1520-6882 ISO Abbreviation: - Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-6-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370536 Medline TA: Anal Chem Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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