Document Detail


Plasmodium yoelii: influence of immune modulators on the development of the liver stage.
MedLine Citation:
PMID:  20493849     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Plasmodium sporozoites suppress the respiratory burst and antigen presentation of Kupffer cells, which are regarded as the portal of invasion into hepatocytes. It is not known whether immune modulation of Kupffer cells can affect the liver stage. In the present study, we found that sporozoites inoculated into Wistar rats could be detected in the liver, spleen, and lung; however, most sporozoites were arrested in the liver. Sporozoites were captured by Kupffer cells lined with endothelial cells in the liver sinusoid before hepatocyte invasion. Pretreatment with TLR3 agonist poly(I:C) and TLR2 agonist BCG primarily activated Kupffer cells, inhibiting the sporozoite development into the exoerythrocytic form, whereas Kupffer cell antagonists dexamethasone and cyclophosphamide promoted development of the liver stage. Our data suggests that sporozoite development into its exoerythrocytic form may be associated with Kupffer cell functional status. Immune modulation of Kupffer cells could be a promising strategy to prevent malaria parasite infection.
Authors:
Xu Wen-yue; Wang Xing-xiang; Qi Jie; Duan Jian-hua; Huang Fu-sheng
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-05-21
Journal Detail:
Title:  Experimental parasitology     Volume:  126     ISSN:  1090-2449     ISO Abbreviation:  Exp. Parasitol.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-08-03     Completed Date:  2010-08-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370713     Medline TA:  Exp Parasitol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  254-8     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Inc. All rights reserved.
Affiliation:
Department of Pathogenic Biology, Third Military Medical University, 30 Gaotanyan Zhengjie, Shapingba District, Chongqing 400038, PR China. xuwenyue@gmail.com
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MeSH Terms
Descriptor/Qualifier:
Adjuvants, Immunologic / pharmacology
Animals
Anopheles
BCG Vaccine / pharmacology
Cryoelectron Microscopy
Cyclophosphamide / pharmacology
Dexamethasone / pharmacology
Female
Glucocorticoids / pharmacology
Immunologic Factors / pharmacology*
Immunosuppressive Agents / pharmacology
Interferon Inducers / pharmacology
Kupffer Cells / parasitology
Liver / parasitology*,  ultrastructure
Lung / parasitology
Male
Microscopy, Electron, Scanning
Plasmodium yoelii / drug effects,  growth & development*,  immunology
Poly I-C / pharmacology
Rats
Rats, Wistar
Spleen / parasitology
Chemical
Reg. No./Substance:
0/Adjuvants, Immunologic; 0/BCG Vaccine; 0/Glucocorticoids; 0/Immunologic Factors; 0/Immunosuppressive Agents; 0/Interferon Inducers; 24939-03-5/Poly I-C; 50-02-2/Dexamethasone; 50-18-0/Cyclophosphamide

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