| Plasmodium vivax clinical malaria is commonly observed in Duffy-negative Malagasy people. | |
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MedLine Citation:
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PMID: 20231434 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Malaria therapy, experimental, and epidemiological studies have shown that erythrocyte Duffy blood group-negative people, largely of African ancestry, are resistant to erythrocyte Plasmodium vivax infection. These findings established a paradigm that the Duffy antigen is required for P. vivax erythrocyte invasion. P. vivax is endemic in Madagascar, where admixture of Duffy-negative and Duffy-positive populations of diverse ethnic backgrounds has occurred over 2 millennia. There, we investigated susceptibility to P. vivax blood-stage infection and disease in association with Duffy blood group polymorphism. Duffy blood group genotyping identified 72% Duffy-negative individuals (FY*B(ES)/*B(ES)) in community surveys conducted at eight sentinel sites. Flow cytometry and adsorption-elution results confirmed the absence of Duffy antigen expression on Duffy-negative erythrocytes. P. vivax PCR positivity was observed in 8.8% (42/476) of asymptomatic Duffy-negative people. Clinical vivax malaria was identified in Duffy-negative subjects with nine P. vivax monoinfections and eight mixed Plasmodium species infections that included P. vivax (4.9 and 4.4% of 183 participants, respectively). Microscopy examination of blood smears confirmed blood-stage development of P. vivax, including gametocytes. Genotyping of polymorphic surface and microsatellite markers suggested that multiple P. vivax strains were infecting Duffy-negative people. In Madagascar, P. vivax has broken through its dependence on the Duffy antigen for establishing human blood-stage infection and disease. Further studies are necessary to identify the parasite and host molecules that enable this Duffy-independent P. vivax invasion of human erythrocytes. |
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Authors:
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Didier Ménard; Céline Barnadas; Christiane Bouchier; Cara Henry-Halldin; Laurie R Gray; Arsène Ratsimbasoa; Vincent Thonier; Jean-François Carod; Olivier Domarle; Yves Colin; Olivier Bertrand; Julien Picot; Christopher L King; Brian T Grimberg; Odile Mercereau-Puijalon; Peter A Zimmerman |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-03-15 |
Journal Detail:
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Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 107 ISSN: 1091-6490 ISO Abbreviation: Proc. Natl. Acad. Sci. U.S.A. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-04-01 Completed Date: 2010-04-28 Revised Date: 2010-10-01 |
Medline Journal Info:
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Nlm Unique ID: 7505876 Medline TA: Proc Natl Acad Sci U S A Country: United States |
Other Details:
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Languages: eng Pagination: 5967-71 Citation Subset: IM |
Affiliation:
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Institut Pasteur de Madagascar, Unité de Recherche sur le Paludisme, Antananarivo 101, Madagascar. dmenard@pasteur.fr |
| Data Bank Information | |
Bank Name/Acc. No.:
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GENBANK/GU130196; GU130197 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent African Continental Ancestry Group / genetics Asian Continental Ancestry Group / genetics Base Sequence Child Child, Preschool DNA Primers / genetics Duffy Blood-Group System* / genetics, immunology Erythrocytes / parasitology Female Genetic Association Studies Host-Parasite Interactions / genetics, immunology Humans Madagascar / epidemiology Malaria, Vivax / blood*, epidemiology, genetics Male Molecular Sequence Data Plasmodium vivax / genetics, growth & development, pathogenicity |
| Grant Support | |
ID/Acronym/Agency:
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AI46919/AI/NIAID NIH HHS; TW007872/TW/FIC NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/DNA Primers; 0/Duffy Blood-Group System |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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