| Plasmodium induced by SU6656, an Src family kinase inhibitor, is accompanied by a contractile ring defect. | |
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MedLine Citation:
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PMID: 22034098 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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We have shown that SU6656, a potent Src family kinase inhibitor, has the ability to induce multinucleation at a high frequency in diverse cells: rat skin fibroblasts, bone marrow adherent cells, 5F9A mesenchymal stem cell-like clones, 2C5 tracheal epithelial cells and MDCK epithelial cells from dog kidney. To gain insight into the mechanism of multinucleation, we observed the process by time-lapse and confocal microscopy. These multinuclei generally seem to exist independently in one cell without any connections with each other. By time-lapse microscopy, multinucleated cells were found to be formed through the mechanism of plasmodium: karyokinesis without cytokinesis. The observation of EGFP-actin transfected cells by time-lapse confocal laser scanning microscopy suggested that plasmodium occurred with deficient contractile ring formation. Although we examined the differentiation of these cells, the multinucleated cells could not be categorized into any type of cell in vivo known to exhibit multinuclei. Copyright © 2011 John Wiley & Sons, Ltd. |
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Authors:
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Keiichiro Yoshida; Michio Ono; Haruhiko Bito; Taro Mikami; Hajime Sawada |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-10-27 |
Journal Detail:
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Title: Cell biochemistry and function Volume: - ISSN: 1099-0844 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8305874 Medline TA: Cell Biochem Funct Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 John Wiley & Sons, Ltd. |
Affiliation:
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Department of Histology and Cell Biology, Yokohama City University School of Medicine, Yokohama, Kanagawa-ken, Japan. k6552@yokohama-cu.ac.jp. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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