Document Detail

Plasmodium falciparum malaria in the first year of life in an area of intense and perennial transmission.
MedLine Citation:
PMID:  8765455     Owner:  NLM     Status:  MEDLINE    
A longitudinal study of Plasmodium falciparum malaria in infants in Idete village, south-eastern Tanzania, was conducted over a period of 14 months in order to determine the incidence of P. falciparum infection and clinical malaria in the first year of life. Of 1356 blood slides from cross-sectional surveys, 52.1% were positive for asexual stages of P. falciparum. There were marked increases in P. falciparum prevalence, parasite densities, overall fever incidence and the incidence of malaria fevers with age for the first 6 months of life. The average attack rate, estimated from a reversible catalytic model, was 0.029 per day with a slight increase with age but there was no initial period of protection against infection in neonates. Estimated average duration of infections was 64 days, with infections in older infants lasting much longer than those contracted during the first 2 months of life. These results support the hypotheses that the main effect of passively transferred maternal immunity to malaria is in the control of asexual stage parasites, and that the level of clinical immunity depends upon the extent of recent exposure to parasites. Infants as young as 4 months of age are at high risk of clinical attacks. Intervention programmes against malaria in areas of the highest transmission should therefore be designed to include this group.
A Y Kitua; T Smith; P L Alonso; H Masanja; H Urassa; C Menendez; J Kimario; M Tanner
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Tropical medicine & international health : TM & IH     Volume:  1     ISSN:  1360-2276     ISO Abbreviation:  Trop. Med. Int. Health     Publication Date:  1996 Aug 
Date Detail:
Created Date:  1996-09-13     Completed Date:  1996-09-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9610576     Medline TA:  Trop Med Int Health     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  475-84     Citation Subset:  IM    
Ifakara Centre, Tanzania.
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MeSH Terms
Cohort Studies
Cross-Sectional Studies
Immunity, Maternally-Acquired
Infant, Newborn
Longitudinal Studies
Malaria, Falciparum / epidemiology*,  immunology,  transmission
Quality Assurance, Health Care
Risk Factors
Rural Population
Tanzania / epidemiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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