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Plasmodium falciparum: Epigenetic Control of var Gene Regulation and Disease.
MedLine Citation:
PMID:  23150271     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Plasmodium, one of the most important members of Apicomplexan protozoans imposes a significant economic and health impact on human populations around the world. Plasmodium parasite has complex life cycle with morphologically distinct asexual and sexual developmental stages in the human host and Anopheline mosquito vector. The parasites undergo rapid transition between morphological states and antigenic variation in order to sustain chronic infection and immune evasion in human host. To achieve all these, parasites adopt various regulatory pathways including transcriptional and posttranscriptional regulation of gene expression, translational repression and posttranslational modification of proteins. These regulatory modes help to respond to host conditions during an acute stage infection or life cycle transition of the parasite.
Authors:
Abhijit S Deshmukh; Sandeep Srivastava; Suman Kumar Dhar
Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Sub-cellular biochemistry     Volume:  61     ISSN:  0306-0225     ISO Abbreviation:  Subcell. Biochem.     Publication Date:  2013  
Date Detail:
Created Date:  2012-11-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0316571     Medline TA:  Subcell Biochem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  659-682     Citation Subset:  -    
Affiliation:
Special Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi, 110067, India.
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