Document Detail

Plasmodium chabaudi AS induces pregnancy loss in association with systemic pro-inflammatory immune responses in A/J and C57BL/6 mice.
MedLine Citation:
PMID:  22251385     Owner:  NLM     Status:  MEDLINE    
The molecular mechanisms that underlie poor birth outcomes in malaria during pregnancy remain poorly defined. To assess the role of host immune responses, mice known to respond differentially to Plasmodium chabaudi AS infection were studied. Following infection at day 0 of pregnancy, A/J mice developed significantly higher parasitemia than C57BL/6 (B6) mice and succumbed to infection. Both strains had evidence of parasite accumulation in the placenta at mid-gestation and aborted, with significantly higher embryo loss in infected A/J mice on day 9. While infection-induced systemic tumour necrosis factor (TNF) and interleukin (IL)-1β in the latter were significantly higher at day 11, day 10 IL-10 levels were higher in B6 mice. No differences in the levels of splenic lymphocyte subsets, neutrophils or monocytes between infected pregnant A/J and B6 mice were observed, with most cell types expanding in response to infection regardless of pregnancy. Antibody ablation of TNF exacerbated infection in A/J mice and did not ameliorate pregnancy outcome. Thus, malaria induces poor pregnancy outcome in both the mouse strains in the context of quantitatively different systemic inflammatory responses. Further evaluation of the roles of soluble and cellular immune components, particularly at the uteroplacental level, will be required to define the most critical pregnancy-compromising mechanisms.
D Sarr; G M Smith; J S Poovassery; T Nagy; J M Moore
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Parasite immunology     Volume:  34     ISSN:  1365-3024     ISO Abbreviation:  Parasite Immunol.     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-03-07     Completed Date:  2012-06-19     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  7910948     Medline TA:  Parasite Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  224-35     Citation Subset:  IM    
Copyright Information:
© 2012 Blackwell Publishing Ltd.
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MeSH Terms
Abortion, Spontaneous / etiology*
Cytokines / metabolism
Inflammation / immunology
Malaria / complications,  immunology*,  parasitology*
Mice, Inbred C57BL
Parasitemia / parasitology
Placenta / parasitology
Plasmodium chabaudi / pathogenicity*
Pregnancy Complications, Parasitic / immunology*,  parasitology
Grant Support
Reg. No./Substance:

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