Document Detail


Plasminogen receptors and their role in the pathogenesis of inflammatory, autoimmune and malignant disease.
MedLine Citation:
PMID:  23140188     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Plasminogen is the proenzyme of plasmin, the key protease of the fibrinolytic system, but its role is not limited to fibrinolysis regulation. Plasminogen binds not only to fibrin, but also to different receptors on cell surfaces, including the heterotetrameric complex Annexin A2 - S100A10, enolase-1, histone H2B and the plasminogen receptor Plg-R(KT) . These receptors localize plasmin generation to the cell surface and provide a broad-spectrum of reactions including proteolytic activity, cell migration and recruitment as well as signalling pathway activation. These plasminogen-binding proteins are involved in both physiologic and pathologic processes such as inflammation, thrombosis and cancer. Thus, plasminogen is at the centre of a complex tightly controlled and regulated system where plasminogen-binding proteins have a crucial role, suggesting new therapeutic and diagnostic strategies. This review will discuss currently available information on plasminogen receptors, particularly their mechanisms of action and their roles in inflammatory, autoimmune and malignant disease. © 2012 International Society on Thrombosis and Haemostasis.
Authors:
A Godier; B J Hunt
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-12
Journal Detail:
Title:  Journal of thrombosis and haemostasis : JTH     Volume:  -     ISSN:  1538-7836     ISO Abbreviation:  J. Thromb. Haemost.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101170508     Medline TA:  J Thromb Haemost     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 International Society on Thrombosis and Haemostasis.
Affiliation:
Department of Anaesthesia and Critical Care, Université Paris Descartes, Groupe Hospitalier Cochin Hôtel-Dieu, and INSERM UMR S765, Université Paris Descartes, Sorbonne Paris Cité, Paris, France Thrombosis & Haemostasis, Kings College: and Depts of Thrombosis & Thrombophilia, Lupus and Pathology, & Director of the Haemostasis Research Unit, Guy's & St Thomas' NHS Foundation Trust, London SE1 7EH.
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