| Plasminogen activators and plasminogen activator inhibitors in plasma of premature and term newborns. | |
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MedLine Citation:
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PMID: 9116413 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To compare the plasminogen activators (tPA, uPA) and their inhibitors (PAI-1, PAI-2) at different gestational ages, related to levels in women at term and non-pregnant women. METHODS: Blood samples were obtained by puncture of the umbilical cord vein, in gestational weeks 39-40 (n = 21), 30-32 (n = 15), and 27-29 (n = 9). Analyses of PA and PAI antigen concentrations and of PAI-1 activity were performed. RESULTS: The mean tPA antigen level in term newborn infants was 14.5 micrograms/l compared to the premature newborns (7.0 micrograms/l), women at term (7.5 micrograms/l) and non-pregnant women (2.3 micrograms/l). PAI-1 activity and PAI-2 antigen concentrations were also higher in term newborn than in premature infants. CONCLUSIONS: The plasma levels of the plasminogen activators and inhibitors are higher in term newborn compared with premature newborn infants, reflecting maturation of protein synthesis. |
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Authors:
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B Astedt; C Lindoff |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta paediatrica (Oslo, Norway : 1992) Volume: 86 ISSN: 0803-5253 ISO Abbreviation: Acta Paediatr. Publication Date: 1997 Jan |
Date Detail:
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Created Date: 1997-04-18 Completed Date: 1997-04-18 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9205968 Medline TA: Acta Paediatr Country: NORWAY |
Other Details:
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Languages: eng Pagination: 111-3 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynaecology, University of Lund, University Hospital, Sweden. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Female Fetal Blood / chemistry Gestational Age Humans Infant, Newborn / blood* Infant, Premature / blood* Plasminogen Activator Inhibitor 1 / blood* Plasminogen Activator Inhibitor 2 / blood* Plasminogen Activators / blood* Pregnancy / blood |
| Chemical | |
Reg. No./Substance:
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0/Plasminogen Activator Inhibitor 1; 0/Plasminogen Activator Inhibitor 2; EC 3.4.21.-/Plasminogen Activators |
| Comments/Corrections | |
Comment In:
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Acta Paediatr. 1997 Sep;86(9):1022-3
[PMID:
9343292
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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