| Plasminogen activator inhibitor-1 in patients with atrial arrhythmias during acute myocardial infarction, treated with streptokinase. | |
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MedLine Citation:
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PMID: 12441914 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Atrial arrhythmias (AA), especially atrial fibrillation (AF), during acute myocardial infarction (AMI) are often associated with increased mortality and heart failure. Impaired fibrinolysis with elevated plasminogen activator inhibitor-1 (PAI-1) activity is associated with resistance to fibrinolytic therapy in AMI patients, but it is also found in patients with AF. Our aim was a prospective study of the role of pre-treatment PAI-1 levels for the presence of AA in AMI patients and the influence of AA on in-hospital mortality. In 116 AMI patients, treated with streptokinase, pre-treatment PAI-1 levels were estimated by the chromogenic method (normal levels, 0.3-3.5 U/ml) and in-hospital AA were assessed as atrial fibrillation, flutter and/or tachycardias. Between patients with and without AA, a significant difference was observed in mean pre-treatment PAI-1 levels, in several in-hospital complications and mortality (24 versus 4.4%; P < 0.01; odds ratio, 6.45; 95% confidence interval, 1.66-25.0). The PAI-1 level > 7 U/ml was the most significant independent pre-treatment risk factor for AA (P < 0.05; odds ratio, 3.5; 95% confidence interval, 1.15-10.6). We conclude that AA were a significant risk for in-hospital mortality of AMI patients, treated with streptokinase. A pre-treatment PAI-1 level > 7 U/ml was the most significant pre-treatment risk for AA in these patients. |
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Authors:
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A Sinkovic |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis Volume: 13 ISSN: 0957-5235 ISO Abbreviation: Blood Coagul. Fibrinolysis Publication Date: 2002 Dec |
Date Detail:
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Created Date: 2002-11-20 Completed Date: 2003-10-10 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9102551 Medline TA: Blood Coagul Fibrinolysis Country: England |
Other Details:
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Languages: eng Pagination: 741-7 Citation Subset: IM |
Affiliation:
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Department for Internal Intensive Medicine, General Hospital Maribor, Slovenia. andreja.sinkovic@guest.arnes.si |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Arrhythmias, Cardiac / blood*, diagnosis, etiology Atrial Fibrillation / blood, diagnosis, etiology Drug Therapy, Combination Electrocardiography Female Heart Atria / physiopathology Hospital Mortality Humans Male Middle Aged Myocardial Infarction / blood, complications, drug therapy* Plasminogen Activator Inhibitor 1 / blood* Predictive Value of Tests Prospective Studies Streptokinase / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Plasminogen Activator Inhibitor 1; EC 3.4.-/Streptokinase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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