| Plasminogen activator inhibitor-1 gene polymorphism 4G/4G genotype and lupus nephritis in Chinese patients. | |
| | |
MedLine Citation:
|
PMID: 11260416 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Abnormal regulation in the coagulation and fibrinolytic system may play an important role in mediating glomerular damage in lupus nephritis. Indeed, glomerular thrombosis occurs frequently in lupus nephritis and predicts the future development of glomerular sclerosis. In the murine model of active lupus nephritis, plasminogen activator inhibitor-1 (PAI-1) gene was overexpressed throughout the kidney, both within the glomeruli and also in tubules and vessels. The level of PAI-1 expression in the tissues appeared to correlate with the progression of lupus nephritis. Recently, a single base pair insertion/deletion 4G/5G polymorphism of the PAI-1 gene has been identified and shown to alter plasma PAI-1 activity. This study was therefore conducted to determine the association of the 4G/5G polymorphism of the PAI-1 gene with the development and severity of lupus nephritis. METHODS: The PAI-1 gene polymorphism of 118 systemic lupus erythematosus (SLE) patients and 103 healthy controls who were gender and age matched was determined using standard polymerase chain reaction. PAI-1 genotype results were studied in relationship to the development and severity of lupus nephritis. RESULTS: Allele frequencies of 4G/5G allele were 0.59/0.41 in lupus patients and 0.59/0.41 in controls (P = 1.000). No significant difference was noted in the genotype distribution between SLE patients with and without nephritis. However, lupus nephritis patients with the 4G4G genotype showed significantly heavier proteinuria (5.0 vs. 3.7 g/day; P = 0.023) when compared with patients with 4G5G and 5G5G genotypes. Also, 73.3% patients with 4G4G had an activity index > or =8 versus 37.3% patients with 4G5G and 5G5G (P = 0.003). Extensive necrotizing lesions were seen in 51.7% patients with 4G4G as compared with 23.5% patients with 4G5G and 5G5G (P = 0.014). The association of the 4G4G gene polymorphism with a higher nephritis activity and more severe necrotizing lesions persisted when only class III and class IV nephritis patients were studied. On the other hand, no significant association was noted between the PAI-1 gene polymorphism and the chronicity of the nephritis. CONCLUSION: These findings suggest that the 4G/5G polymorphism of the PAI-1 gene is associated with the activity but not the chronicity of lupus nephritis. The presence of the 4G4G genotype does not increase the risk of developing SLE or lupus nephritis, but predicts the development of higher nephritis activity and more extensive necrotizing lesions. |
| | |
Authors:
|
A Y Wang; P Poon; F M Lai; L Yu; P C Choi; S F Lui; P K Li |
Related Documents
:
|
16344016 - A new snp in a negative regulatory region of the cyp19a1 gene is associated with lumbar... 9152986 - No association between the serotonin transporter gene regulatory region polymorphism an... 17579196 - Risk factors for hypospadias in the estrogen receptor 2 gene. 14973356 - Lack of association between perlecan gene intron 6 bamhi polymorphism and risk of mitra... 21854676 - Genetic manipulation of schistosomes - progress with integration competent vectors. 12468096 - Expression patterns and gene distribution in the human genome. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Kidney international Volume: 59 ISSN: 0085-2538 ISO Abbreviation: Kidney Int. Publication Date: 2001 Apr |
Date Detail:
|
Created Date: 2001-03-22 Completed Date: 2001-06-14 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0323470 Medline TA: Kidney Int Country: United States |
Other Details:
|
Languages: eng Pagination: 1520-8 Citation Subset: IM |
Affiliation:
|
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, The Prince of Wales Hospital, Hong Kong, China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Alleles Asian Continental Ancestry Group / genetics* China Female Gene Frequency Genotype Humans Kidney / pathology Lupus Nephritis / genetics*, pathology, urine Male Necrosis Plasminogen Activator Inhibitor 1 / genetics* Polymorphism, Genetic / genetics* Proteinuria / urine Reference Values |
| Chemical | |
Reg. No./Substance:
|
0/Plasminogen Activator Inhibitor 1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Incidence, risk factors, and prognosis of gastrointestinal hemorrhage complicating acute renal failu...
Next Document: Bicarbonate/lactate-based peritoneal dialysis solution increases cancer antigen 125 and decreases hy...