| Plasmin in tear fluid of patients with corneal ulcers: basis for new therapy. | |
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MedLine Citation:
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PMID: 2437758 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In a patient with chronic corneal ulcer, resistant to conventional therapy, analysis of tear fluid revealed a high plasmin activity which could be inhibited by aprotinin, an inhibitor of serine proteinases. Therapy with topical aprotinin resulted in rapid epithelialization. After this initial patient, within a period of four months tear fluid specimens of altogether 48 patients with corneal lesions were analyzed, and 32 were found to be positive for proteolytic activity. Of these 18 were treated with topical aprotinin which rapidly promoted corneal epithelial healing. Six of these patients had been treated with conventional therapy for 3-10 weeks but proved to be completely therapy-resistant. Our observations on three successfully treated patients with chemical burns of the cornea indicated appearance of plasmin in tear fluid after a few days correlating with cessation of epithelialization. In all patients, in which tear fluid plasmin activity was followed, the activity disappeared during aprotinin therapy correlating with corneal re-epithelialization. In some patients with low proteolytic activity aprotinin was combined with fibronectin with a beneficial therapeutic effect. No proteolytic activity was found in the tear fluid of control individuals. These preliminary data indicate that in patients with treatment-resistant corneal lesions inhibition of proteolytic activity can assist in epithelial healing. Such an inhibition is likely to be a prerequisite for the proteinase-sensitive cell adhesion proteins such as fibronectin to promote epithelialization. |
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Authors:
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E M Salonen; T Tervo; E Törmä; A Tarkkanen; A Vaheri |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta ophthalmologica Volume: 65 ISSN: 0001-639X ISO Abbreviation: Acta Ophthalmol (Copenh) Publication Date: 1987 Feb |
Date Detail:
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Created Date: 1987-05-27 Completed Date: 1987-05-27 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 0370347 Medline TA: Acta Ophthalmol (Copenh) Country: DENMARK |
Other Details:
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Languages: eng Pagination: 3-12 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Topical Adult Aged Aprotinin / therapeutic use* Clinical Trials as Topic Corneal Ulcer / drug therapy, metabolism* Drug Therapy, Combination Female Fibrinolysin / antagonists & inhibitors, metabolism* Fibronectins / therapeutic use Humans Infant Male Middle Aged Tears / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Fibronectins; 9087-70-1/Aprotinin; EC 3.4.21.7/Fibrinolysin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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