Document Detail


Plasmid-templated shape control of condensed DNA-block copolymer nanoparticles.
MedLine Citation:
PMID:  23055399     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
DNA-containing micellar nanoparticles with distinctly different and highly uniform morphologies are prepared via condensation of plasmid DNA with a block copolymer of polyethylene glycol and a polycation in solvents of different polarity. Molecular dynamics simulations explain the underlying mechanism.
Authors:
Xuan Jiang; Wei Qu; Deng Pan; Yong Ren; John-Michael Williford; Honggang Cui; Erik Luijten; Hai-Quan Mao
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2012-10-11
Journal Detail:
Title:  Advanced materials (Deerfield Beach, Fla.)     Volume:  25     ISSN:  1521-4095     ISO Abbreviation:  Adv. Mater. Weinheim     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-08     Completed Date:  2013-09-27     Revised Date:  2014-02-14    
Medline Journal Info:
Nlm Unique ID:  9885358     Medline TA:  Adv Mater     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  227-32     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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MeSH Terms
Descriptor/Qualifier:
Amides / chemistry
DNA / chemistry*
Dimethylformamide / chemistry
Micelles
Nanoparticles / chemistry*
Phosphoric Acids / chemistry
Plasmids / chemistry*
Polyethylene Glycols / chemistry
Polymers / chemistry*
Water / chemistry
Grant Support
ID/Acronym/Agency:
R01 GM073937/GM/NIGMS NIH HHS; R01DK068399/DK/NIDDK NIH HHS; R01GM073937/GM/NIGMS NIH HHS; R21 EB013274/EB/NIBIB NIH HHS; R21 EB015152/EB/NIBIB NIH HHS; R21EB013274/EB/NIBIB NIH HHS; U54CA151838/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Amides; 0/Micelles; 0/Phosphoric Acids; 0/Polyethylene Glycols; 0/Polymers; 059QF0KO0R/Water; 8696NH0Y2X/Dimethylformamide; 9007-49-2/DNA; 9Q189608GB/phosphoramidic acid
Comments/Corrections

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